The table below lists the options of the executed module.
Option | Value |
---|---|
analyze.sites | no |
region.types | cpgislands, genes, promoters, tiling1kb, gencode22promoters, ensembleRegBuildBPall |
differential.permutations | 0 |
differential.comparison.columns | cmp_ct_mono_vs_neut, cmp_ct_mono_vs_neut_VB, cmp_ct_mono_vs_mf, cmp_ct_mono_vs_mf_VB, cmp_ct_TCD4_TN_vs_CM, cmp_ct_TCD4_TN_vs_EM, cmp_ct_TCD4_CM_vs_EM, cmp_ct_TCD8_TN_vs_CM, cmp_ct_TCD8_TN_vs_EM, cmp_ct_TCD8_CM_vs_EM, cmp_ct_neut_myel_vs_meta, cmp_ct_neut_meta_vs_band, cmp_ct_neut_band_vs_segm, cmp_ct_neut_early_vs_mature |
differential.comparison.columns.all.pairwise | default |
columns.pairing | default |
differential.site.test.method | limma |
covariate.adjustment.columns | tissueTypeShort, DONOR_SEX |
differential.adjustment.sva | yes |
differential.adjustment.celltype | yes |
differential.enrichment.go | yes |
differential.enrichment.lola | yes |
differential.enrichment.lola.dbs | ${LOLACore}, ${LOLAExt} |
Differential methylation analysis was conducted on site and region level according to the sample groups specified in the analysis.
The following comparisons were made:
The table below summarizes information on the comparisons.
comparison | adjustment | covariateTable | |
1 | mono vs. neut (based on cmp_ct_mono_vs_neut) | tissueTypeShort,DONOR_SEX | csv |
2 | mono vs. neut (based on cmp_ct_mono_vs_neut_VB) | DONOR_SEX | csv |
3 | Mf vs. mono (based on cmp_ct_mono_vs_mf) | tissueTypeShort,DONOR_SEX | csv |
4 | Mf vs. mono (based on cmp_ct_mono_vs_mf_VB) | DONOR_SEX | csv |
5 | EM vs. TN (based on cmp_ct_TCD4_TN_vs_CM) | DONOR_SEX | csv |
6 | EM vs. TN (based on cmp_ct_TCD4_TN_vs_EM) | DONOR_SEX | csv |
7 | CM vs. EM (based on cmp_ct_TCD4_CM_vs_EM) | DONOR_SEX | csv |
8 | EM vs. TN (based on cmp_ct_TCD8_TN_vs_CM) | tissueTypeShort,DONOR_SEX | csv |
9 | EM vs. TN (based on cmp_ct_TCD8_TN_vs_EM) | tissueTypeShort,DONOR_SEX | csv |
10 | CM vs. EM (based on cmp_ct_TCD8_CM_vs_EM) | DONOR_SEX | csv |
11 | meta vs. myel (based on cmp_ct_neut_myel_vs_meta) | DONOR_SEX | csv |
12 | band vs. meta (based on cmp_ct_neut_meta_vs_band) | DONOR_SEX | csv |
13 | band vs. segm (based on cmp_ct_neut_band_vs_segm) | DONOR_SEX | csv |
14 | early vs. mature (based on cmp_ct_neut_early_vs_mature) | tissueTypeShort,DONOR_SEX | csv |
In the following anlyses, p-values on the site level were computed using the limma
method. I.e. hierarchical linear models from the limma package were employed and fitted using an empirical Bayes approach on derived M-values.
Differential methylation on the region level was computed based on a variety of metrics. Of particular interest for the following plots and analyses are the following quantities for each region: the mean methylation difference in a region of the two groups being and of quotient of mean methylation levelsas well as a p-value obtained from statistical testing (limma or t-test; depending on parameter settings). Additionally each region was assigned a rank based on each of these three criteria. A combined rank is computed as the maximum (i.e. worst) value among the three ranks. The smaller the combined rank for a region, the more evidence for differential methylation it exhibits. Regions were defined based on the region types specified in the analysis. This section includes scatterplots of the region group means as well as volcano plots of each pairwise comparison colored according to the combined rank of a given region.
The following rank cutfoffs have been automatically selected for the analysis of differentially methylated regions:
cpgislands | genes | promoters | tiling1kb | gencode22promoters | ensembleRegBuildBPall | |
mono vs. neut (based on cmp_ct_mono_vs_neut) | 0 | 0 | 0 | 0 | 0 | 0 |
mono vs. neut (based on cmp_ct_mono_vs_neut_VB) | 0 | 0 | 0 | 0 | 0 | 0 |
Mf vs. mono (based on cmp_ct_mono_vs_mf) | 0 | 0 | 0 | 0 | 0 | 0 |
Mf vs. mono (based on cmp_ct_mono_vs_mf_VB) | 0 | 0 | 0 | 0 | 0 | 0 |
EM vs. TN (based on cmp_ct_TCD4_TN_vs_CM) | 0 | 0 | 0 | 0 | 0 | 0 |
EM vs. TN (based on cmp_ct_TCD4_TN_vs_EM) | 0 | 0 | 0 | 0 | 0 | 0 |
CM vs. EM (based on cmp_ct_TCD4_CM_vs_EM) | 0 | 0 | 0 | 0 | 0 | 0 |
EM vs. TN (based on cmp_ct_TCD8_TN_vs_CM) | 0 | 0 | 0 | 0 | 0 | 0 |
EM vs. TN (based on cmp_ct_TCD8_TN_vs_EM) | 0 | 0 | 0 | 0 | 0 | 0 |
CM vs. EM (based on cmp_ct_TCD8_CM_vs_EM) | 0 | 0 | 0 | 0 | 0 | 0 |
meta vs. myel (based on cmp_ct_neut_myel_vs_meta) | 0 | 0 | 0 | 0 | 0 | 0 |
band vs. meta (based on cmp_ct_neut_meta_vs_band) | 0 | 0 | 0 | 0 | 0 | 0 |
band vs. segm (based on cmp_ct_neut_band_vs_segm) | 0 | 0 | 0 | 0 | 0 | 0 |
early vs. mature (based on cmp_ct_neut_early_vs_mature) | 0 | 0 | 0 | 0 | 0 | 0 |
comparison | |
regions | |
differential methylation measure |
Scatterplot for differential methylation (regions). If the selected criterion is not rankGradient
:
The transparency corresponds to point density. The 1% of the points in the sparsest populated plot regions are drawn explicitly.
Additionally, the colored points represent differentially methylated regions (according to the selected criterion).
If the selected criterion is rankGradient
: median combined ranks accross hexagonal bins are shown
as a gradient according to the color legend.
comparison | |
regions | |
difference metric | |
significance metric |
Volcano plot for differential methylation quantified by various metrics. Color scale according to combined ranking.
A tabular overview of measures for differential methylation on the region level for the individual comparisons are provided in this section.
The tables for the individual comparisons can be found here:
cpgislands | genes | promoters | tiling1kb | gencode22promoters | ensembleRegBuildBPall | |
mono vs. neut (based on cmp_ct_mono_vs_neut) | csv | csv | csv | csv | csv | csv |
mono vs. neut (based on cmp_ct_mono_vs_neut_VB) | csv | csv | csv | csv | csv | csv |
Mf vs. mono (based on cmp_ct_mono_vs_mf) | csv | csv | csv | csv | csv | csv |
Mf vs. mono (based on cmp_ct_mono_vs_mf_VB) | csv | csv | csv | csv | csv | csv |
EM vs. TN (based on cmp_ct_TCD4_TN_vs_CM) | csv | csv | csv | csv | csv | csv |
EM vs. TN (based on cmp_ct_TCD4_TN_vs_EM) | csv | csv | csv | csv | csv | csv |
CM vs. EM (based on cmp_ct_TCD4_CM_vs_EM) | csv | csv | csv | csv | csv | csv |
EM vs. TN (based on cmp_ct_TCD8_TN_vs_CM) | csv | csv | csv | csv | csv | csv |
EM vs. TN (based on cmp_ct_TCD8_TN_vs_EM) | csv | csv | csv | csv | csv | csv |
CM vs. EM (based on cmp_ct_TCD8_CM_vs_EM) | csv | csv | csv | csv | csv | csv |
meta vs. myel (based on cmp_ct_neut_myel_vs_meta) | csv | csv | csv | csv | csv | csv |
band vs. meta (based on cmp_ct_neut_meta_vs_band) | csv | csv | csv | csv | csv | csv |
band vs. segm (based on cmp_ct_neut_band_vs_segm) | csv | csv | csv | csv | csv | csv |
early vs. mature (based on cmp_ct_neut_early_vs_mature) | csv | csv | csv | csv | csv | csv |
Differential variability on the region level was computed similar to differential methylation, but the mean of variances, the log-ratio of the quotient of variances as well as the p-values from the differentiality test were employed. Ranking was performed in line with the ranking of differential methylation.
The following rank cutoffs have been automatically selected for the analysis of differentially variable regions:
cpgislands | genes | promoters | tiling1kb | gencode22promoters | ensembleRegBuildBPall | |
mono vs. neut (based on cmp_ct_mono_vs_neut) | 0 | 0 | 0 | 0 | 0 | 0 |
mono vs. neut (based on cmp_ct_mono_vs_neut_VB) | 0 | 0 | 0 | 0 | 0 | 0 |
Mf vs. mono (based on cmp_ct_mono_vs_mf) | 0 | 0 | 0 | 0 | 0 | 0 |
Mf vs. mono (based on cmp_ct_mono_vs_mf_VB) | 0 | 0 | 0 | 0 | 0 | 0 |
EM vs. TN (based on cmp_ct_TCD4_TN_vs_CM) | 0 | 0 | 0 | 0 | 0 | 0 |
EM vs. TN (based on cmp_ct_TCD4_TN_vs_EM) | 0 | 0 | 0 | 0 | 0 | 0 |
CM vs. EM (based on cmp_ct_TCD4_CM_vs_EM) | 0 | 0 | 0 | 0 | 0 | 0 |
EM vs. TN (based on cmp_ct_TCD8_TN_vs_CM) | 0 | 0 | 0 | 0 | 0 | 0 |
EM vs. TN (based on cmp_ct_TCD8_TN_vs_EM) | 0 | 0 | 0 | 0 | 0 | 0 |
CM vs. EM (based on cmp_ct_TCD8_CM_vs_EM) | 0 | 0 | 0 | 0 | 0 | 0 |
meta vs. myel (based on cmp_ct_neut_myel_vs_meta) | 0 | 0 | 0 | 0 | 0 | 0 |
band vs. meta (based on cmp_ct_neut_meta_vs_band) | 0 | 0 | 0 | 0 | 0 | 0 |
band vs. segm (based on cmp_ct_neut_band_vs_segm) | 0 | 0 | 0 | 0 | 0 | 0 |
early vs. mature (based on cmp_ct_neut_early_vs_mature) | 0 | 0 | 0 | 0 | 0 | 0 |
comparison | |
regions | |
differential variability measure |
Scatterplot for differential variable regions. The transparency corresponds to point density. The 1% of the points in the sparsest populated plot regions are drawn explicitly. Additionally, the colored points represent differentially methylated regions (according to the selected criterion).
GO Enrichment Analysis was conducted. The wordclouds and tables below contains significant GO terms as determined by a hypergeometric test.
comparison | |
Hypermethylation/hypomethylation | |
ontology | |
regions | |
differential methylation measure |
Wordclouds for GO enrichment terms.
comparison | |
Hypermethylation/hypomethylation | |
ontology | |
regions | |
differential methylation measure |
NA. |
n/a |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:2000113 | 0 | 9.2514 | 2.0861 | 11 | 1472 | negative regulation of cellular macromolecule biosynthetic process |
GO:0009890 | 0 | 8.2421 | 2.3143 | 11 | 1633 | negative regulation of biosynthetic process |
GO:0010629 | 0 | 7.2953 | 2.5793 | 11 | 1820 | negative regulation of gene expression |
GO:0009790 | 0 | 8.8411 | 1.318 | 8 | 930 | embryo development |
GO:2000774 | 1e-04 | 171.3968 | 0.0156 | 2 | 11 | positive regulation of cellular senescence |
GO:0042127 | 2e-04 | 6.044 | 2.2208 | 9 | 1567 | regulation of cell proliferation |
GO:0043583 | 2e-04 | 16.8484 | 0.2891 | 4 | 204 | ear development |
GO:0009653 | 2e-04 | 5.286 | 3.4098 | 11 | 2406 | anatomical structure morphogenesis |
GO:0080090 | 2e-04 | 5.093 | 8.234 | 17 | 5810 | regulation of primary metabolic process |
GO:0007389 | 2e-04 | 10.865 | 0.5796 | 5 | 409 | pattern specification process |
GO:0090596 | 4e-04 | 13.8298 | 0.3501 | 4 | 247 | sensory organ morphogenesis |
GO:0044271 | 5e-04 | 4.4463 | 6.8338 | 15 | 4822 | cellular nitrogen compound biosynthetic process |
GO:0000122 | 5e-04 | 7.2531 | 1.0742 | 6 | 758 | negative regulation of transcription from RNA polymerase II promoter |
GO:0021884 | 6e-04 | 64.2143 | 0.0368 | 2 | 26 | forebrain neuron development |
GO:1903507 | 7e-04 | 5.8314 | 1.6128 | 7 | 1138 | negative regulation of nucleic acid-templated transcription |
GO:0051094 | 0.001 | 5.4808 | 1.7077 | 7 | 1205 | positive regulation of developmental process |
GO:0051253 | 0.0011 | 5.4464 | 1.7177 | 7 | 1212 | negative regulation of RNA metabolic process |
GO:0060429 | 0.0011 | 5.4464 | 1.7177 | 7 | 1212 | epithelium development |
GO:0021723 | 0.0014 | Inf | 0.0014 | 1 | 1 | medullary reticular formation development |
GO:0048894 | 0.0014 | Inf | 0.0014 | 1 | 1 | efferent axon development in a lateral line nerve |
GO:0061452 | 0.0014 | Inf | 0.0014 | 1 | 1 | retrotrapezoid nucleus neuron differentiation |
GO:1903769 | 0.0014 | Inf | 0.0014 | 1 | 1 | negative regulation of cell proliferation in bone marrow |
GO:0090342 | 0.0015 | 39.4799 | 0.0581 | 2 | 41 | regulation of cell aging |
GO:0034249 | 0.0016 | 9.2404 | 0.5173 | 4 | 365 | negative regulation of cellular amide metabolic process |
GO:0010556 | 0.0017 | 10.3166 | 0.5579 | 4 | 593 | regulation of macromolecule biosynthetic process |
GO:0021545 | 0.0021 | 33.4576 | 0.068 | 2 | 48 | cranial nerve development |
GO:0048519 | 0.0022 | 3.6114 | 6.9344 | 14 | 4893 | negative regulation of biological process |
GO:0065007 | 0.0026 | 9.6495 | 15.9961 | 22 | 11287 | biological regulation |
GO:0021852 | 0.0028 | 736.5909 | 0.0028 | 1 | 2 | pyramidal neuron migration |
GO:0021934 | 0.0028 | 736.5909 | 0.0028 | 1 | 2 | hindbrain tangential cell migration |
GO:0048925 | 0.0028 | 736.5909 | 0.0028 | 1 | 2 | lateral line system development |
GO:0071228 | 0.0028 | 736.5909 | 0.0028 | 1 | 2 | cellular response to tumor cell |
GO:0072272 | 0.0028 | 736.5909 | 0.0028 | 1 | 2 | proximal/distal pattern formation involved in metanephric nephron development |
GO:0110023 | 0.0028 | 736.5909 | 0.0028 | 1 | 2 | negative regulation of cardiac muscle myoblast proliferation |
GO:1901003 | 0.0028 | 736.5909 | 0.0028 | 1 | 2 | negative regulation of fermentation |
GO:0048731 | 0.0029 | 3.4751 | 6.2712 | 13 | 4425 | system development |
GO:0021872 | 0.0031 | 26.9825 | 0.0836 | 2 | 59 | forebrain generation of neurons |
GO:0042733 | 0.0036 | 25.2069 | 0.0893 | 2 | 63 | embryonic digit morphogenesis |
GO:0006355 | 0.0041 | 3.4056 | 4.8866 | 11 | 3448 | regulation of transcription, DNA-templated |
GO:0010660 | 0.0041 | 23.29 | 0.0964 | 2 | 68 | regulation of muscle cell apoptotic process |
GO:0048663 | 0.0041 | 23.29 | 0.0964 | 2 | 68 | neuron fate commitment |
GO:0003358 | 0.0042 | 368.2727 | 0.0043 | 1 | 3 | noradrenergic neuron development |
GO:0030538 | 0.0042 | 368.2727 | 0.0043 | 1 | 3 | embryonic genitalia morphogenesis |
GO:0035986 | 0.0042 | 368.2727 | 0.0043 | 1 | 3 | senescence-associated heterochromatin focus assembly |
GO:0036023 | 0.0042 | 368.2727 | 0.0043 | 1 | 3 | embryonic skeletal limb joint morphogenesis |
GO:0044336 | 0.0042 | 368.2727 | 0.0043 | 1 | 3 | canonical Wnt signaling pathway involved in negative regulation of apoptotic process |
GO:0048619 | 0.0042 | 368.2727 | 0.0043 | 1 | 3 | embryonic hindgut morphogenesis |
GO:0140076 | 0.0042 | 368.2727 | 0.0043 | 1 | 3 | negative regulation of lipoprotein transport |
GO:2000111 | 0.0042 | 368.2727 | 0.0043 | 1 | 3 | positive regulation of macrophage apoptotic process |
GO:2001141 | 0.0044 | 3.3719 | 4.9248 | 11 | 3475 | regulation of RNA biosynthetic process |
GO:0031326 | 0.0048 | 7.6056 | 0.7433 | 4 | 790 | regulation of cellular biosynthetic process |
GO:0035195 | 0.0056 | 9.3829 | 0.3656 | 3 | 258 | gene silencing by miRNA |
GO:0007198 | 0.0057 | 245.5 | 0.0057 | 1 | 4 | adenylate cyclase-inhibiting serotonin receptor signaling pathway |
GO:0072086 | 0.0057 | 245.5 | 0.0057 | 1 | 4 | specification of loop of Henle identity |
GO:1901166 | 0.0057 | 245.5 | 0.0057 | 1 | 4 | neural crest cell migration involved in autonomic nervous system development |
GO:0048562 | 0.0059 | 9.214 | 0.3742 | 3 | 276 | embryonic organ morphogenesis |
GO:0006417 | 0.006 | 6.313 | 0.7469 | 4 | 527 | regulation of translation |
GO:0016441 | 0.006 | 9.1282 | 0.3756 | 3 | 265 | posttranscriptional gene silencing |
GO:0001656 | 0.0062 | 18.7271 | 0.119 | 2 | 84 | metanephros development |
GO:1901576 | 0.0066 | 3.1178 | 8.6464 | 15 | 6101 | organic substance biosynthetic process |
GO:0043009 | 0.0068 | 6.0727 | 0.7752 | 4 | 547 | chordate embryonic development |
GO:0002568 | 0.0071 | 184.1136 | 0.0071 | 1 | 5 | somatic diversification of T cell receptor genes |
GO:0015870 | 0.0071 | 184.1136 | 0.0071 | 1 | 5 | acetylcholine transport |
GO:0016199 | 0.0071 | 184.1136 | 0.0071 | 1 | 5 | axon midline choice point recognition |
GO:0033153 | 0.0071 | 184.1136 | 0.0071 | 1 | 5 | T cell receptor V(D)J recombination |
GO:0051172 | 0.0071 | 3.9564 | 2.4469 | 7 | 2043 | negative regulation of nitrogen compound metabolic process |
GO:0035282 | 0.0074 | 17.054 | 0.1304 | 2 | 92 | segmentation |
GO:0007568 | 0.0075 | 8.4095 | 0.4067 | 3 | 287 | aging |
GO:0031047 | 0.0075 | 8.3795 | 0.4082 | 3 | 288 | gene silencing by RNA |
GO:0031324 | 0.0076 | 3.9739 | 2.4897 | 7 | 2194 | negative regulation of cellular metabolic process |
GO:0042472 | 0.0078 | 16.6812 | 0.1332 | 2 | 94 | inner ear morphogenesis |
GO:0009953 | 0.0079 | 16.5008 | 0.1346 | 2 | 95 | dorsal/ventral pattern formation |
GO:0003360 | 0.0085 | 147.2818 | 0.0085 | 1 | 6 | brainstem development |
GO:0014062 | 0.0085 | 147.2818 | 0.0085 | 1 | 6 | regulation of serotonin secretion |
GO:0033504 | 0.0099 | 122.7273 | 0.0099 | 1 | 7 | floor plate development |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0070475 | 0 | 514.6349 | 0.0061 | 2 | 9 | rRNA base methylation |
GO:0000154 | 3e-04 | 105.7778 | 0.0244 | 2 | 36 | rRNA modification |
GO:1901506 | 7e-04 | Inf | 7e-04 | 1 | 1 | regulation of acylglycerol transport |
GO:1905884 | 7e-04 | Inf | 7e-04 | 1 | 1 | negative regulation of triglyceride transport |
GO:0001510 | 8e-04 | 59.8444 | 0.042 | 2 | 62 | RNA methylation |
GO:0003245 | 0.002 | 810.8 | 0.002 | 1 | 3 | cardiac muscle tissue growth involved in heart morphogenesis |
GO:0010868 | 0.002 | 810.8 | 0.002 | 1 | 3 | negative regulation of triglyceride biosynthetic process |
GO:0071072 | 0.0034 | 405.35 | 0.0034 | 1 | 5 | negative regulation of phospholipid biosynthetic process |
GO:1904684 | 0.0054 | 231.5857 | 0.0054 | 1 | 8 | negative regulation of metalloendopeptidase activity |
GO:1905205 | 0.0088 | 135.05 | 0.0088 | 1 | 13 | positive regulation of connective tissue replacement |
GO:0010666 | 0.0095 | 124.6538 | 0.0095 | 1 | 14 | positive regulation of cardiac muscle cell apoptotic process |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0050911 | 4e-04 | 32.3111 | 0.16 | 3 | 371 | detection of chemical stimulus involved in sensory perception of smell |
GO:0009593 | 7e-04 | 26.4681 | 0.1941 | 3 | 450 | detection of chemical stimulus |
GO:0050906 | 7e-04 | 25.7565 | 0.1993 | 3 | 462 | detection of stimulus involved in sensory perception |
GO:0007606 | 8e-04 | 25.4145 | 0.2019 | 3 | 468 | sensory perception of chemical stimulus |
GO:0021891 | 0.0026 | 540.5667 | 0.0026 | 1 | 6 | olfactory bulb interneuron development |
GO:0021930 | 0.0043 | 300.2407 | 0.0043 | 1 | 10 | cerebellar granule cell precursor proliferation |
GO:0021534 | 0.0047 | 270.2 | 0.0047 | 1 | 11 | cell proliferation in hindbrain |
GO:0015671 | 0.0065 | 192.9524 | 0.0065 | 1 | 15 | oxygen transport |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:1904628 | 0 | 1351.4167 | 0.003 | 2 | 8 | cellular response to phorbol 13-acetate 12-myristate |
GO:0050918 | 2e-04 | 146.9818 | 0.0211 | 2 | 57 | positive chemotaxis |
GO:0002548 | 2e-04 | 134.6917 | 0.0229 | 2 | 62 | monocyte chemotaxis |
GO:0050829 | 3e-04 | 109.1149 | 0.0281 | 2 | 76 | defense response to Gram-negative bacterium |
GO:0050830 | 4e-04 | 97.2289 | 0.0314 | 2 | 85 | defense response to Gram-positive bacterium |
GO:0060326 | 0.0037 | 30.9399 | 0.0961 | 2 | 260 | cell chemotaxis |
GO:0050900 | 0.0088 | 19.578 | 0.1501 | 2 | 406 | leukocyte migration |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0050832 | 2e-04 | 124.9653 | 0.0216 | 2 | 39 | defense response to fungus |
GO:0061844 | 3e-04 | 94.2915 | 0.0283 | 2 | 51 | antimicrobial humoral immune response mediated by antimicrobial peptide |
GO:0007634 | 6e-04 | Inf | 6e-04 | 1 | 1 | optokinetic behavior |
GO:0021560 | 0.0011 | 2027.375 | 0.0011 | 1 | 2 | abducens nerve development |
GO:0021599 | 0.0011 | 2027.375 | 0.0011 | 1 | 2 | abducens nerve formation |
GO:0035606 | 0.0011 | 2027.375 | 0.0011 | 1 | 2 | peptidyl-cysteine S-trans-nitrosylation |
GO:0044657 | 0.0011 | 2027.375 | 0.0011 | 1 | 2 | pore formation in membrane of other organism during symbiotic interaction |
GO:0052043 | 0.0011 | 2027.375 | 0.0011 | 1 | 2 | modification by symbiont of host cellular component |
GO:0052185 | 0.0011 | 2027.375 | 0.0011 | 1 | 2 | modification of structure of other organism involved in symbiotic interaction |
GO:0052332 | 0.0011 | 2027.375 | 0.0011 | 1 | 2 | modification by organism of membrane in other organism involved in symbiotic interaction |
GO:0060876 | 0.0011 | 2027.375 | 0.0011 | 1 | 2 | semicircular canal formation |
GO:0070488 | 0.0011 | 2027.375 | 0.0011 | 1 | 2 | neutrophil aggregation |
GO:0048702 | 0.0033 | 405.375 | 0.0033 | 1 | 6 | embryonic neurocranium morphogenesis |
GO:0051673 | 0.0033 | 405.375 | 0.0033 | 1 | 6 | membrane disruption in other organism |
GO:0042473 | 0.005 | 253.3125 | 0.005 | 1 | 9 | outer ear morphogenesis |
GO:0060872 | 0.005 | 253.3125 | 0.005 | 1 | 9 | semicircular canal development |
GO:0070475 | 0.005 | 253.3125 | 0.005 | 1 | 9 | rRNA base methylation |
GO:0097398 | 0.005 | 253.3125 | 0.005 | 1 | 9 | cellular response to interleukin-17 |
GO:0030595 | 0.0051 | 23.2386 | 0.1104 | 2 | 199 | leukocyte chemotaxis |
GO:0006959 | 0.0061 | 21.1693 | 0.1209 | 2 | 218 | humoral immune response |
GO:0017014 | 0.0066 | 184.1932 | 0.0067 | 1 | 12 | protein nitrosylation |
GO:0032119 | 0.0066 | 184.1932 | 0.0067 | 1 | 12 | sequestering of zinc ion |
GO:0042742 | 0.0072 | 19.3511 | 0.132 | 2 | 238 | defense response to bacterium |
GO:0002523 | 0.0077 | 155.8365 | 0.0078 | 1 | 14 | leukocyte migration involved in inflammatory response |
GO:0051852 | 0.0077 | 155.8365 | 0.0078 | 1 | 14 | disruption by host of symbiont cells |
GO:0030322 | 0.0088 | 135.0417 | 0.0089 | 1 | 16 | stabilization of membrane potential |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0002263 | 1e-04 | 31.588 | 0.2851 | 4 | 661 | cell activation involved in immune response |
GO:0002275 | 6e-04 | 31.1647 | 0.1876 | 3 | 507 | myeloid cell activation involved in immune response |
GO:0050868 | 7e-04 | 67.1917 | 0.0423 | 2 | 98 | negative regulation of T cell activation |
GO:0043312 | 8e-04 | 25.4709 | 0.2014 | 3 | 467 | neutrophil degranulation |
GO:0042119 | 8e-04 | 24.8637 | 0.2062 | 3 | 478 | neutrophil activation |
GO:0002444 | 0.0011 | 22.6471 | 0.2256 | 3 | 523 | myeloid leukocyte mediated immunity |
GO:0071626 | 0.0013 | 1351.6667 | 0.0013 | 1 | 3 | mastication |
GO:0098583 | 0.0013 | 1351.6667 | 0.0013 | 1 | 3 | learned vocalization behavior |
GO:1905747 | 0.0013 | 1351.6667 | 0.0013 | 1 | 3 | negative regulation of saliva secretion |
GO:1905748 | 0.0013 | 1351.6667 | 0.0013 | 1 | 3 | hard palate morphogenesis |
GO:0002695 | 0.0017 | 43.7415 | 0.0643 | 2 | 149 | negative regulation of leukocyte activation |
GO:2000552 | 0.0017 | 901.0556 | 0.0017 | 1 | 4 | negative regulation of T-helper 2 cell cytokine production |
GO:0022408 | 0.0018 | 43.149 | 0.0651 | 2 | 151 | negative regulation of cell-cell adhesion |
GO:0045321 | 0.002 | 23.3071 | 0.3032 | 3 | 975 | leukocyte activation |
GO:0046903 | 0.002 | 13.1151 | 0.6474 | 4 | 1501 | secretion |
GO:0007356 | 0.0022 | 675.75 | 0.0022 | 1 | 5 | thorax and anterior abdomen determination |
GO:0021650 | 0.0022 | 675.75 | 0.0022 | 1 | 5 | vestibulocochlear nerve formation |
GO:1901078 | 0.0022 | 675.75 | 0.0022 | 1 | 5 | negative regulation of relaxation of muscle |
GO:0045055 | 0.0025 | 16.483 | 0.3058 | 3 | 709 | regulated exocytosis |
GO:0045343 | 0.003 | 450.4444 | 0.003 | 1 | 7 | regulation of MHC class I biosynthetic process |
GO:0006959 | 0.0036 | 29.6407 | 0.094 | 2 | 218 | humoral immune response |
GO:0021562 | 0.0039 | 337.7917 | 0.0039 | 1 | 9 | vestibulocochlear nerve development |
GO:0042742 | 0.0043 | 27.0949 | 0.1027 | 2 | 238 | defense response to bacterium |
GO:0030432 | 0.0043 | 300.2407 | 0.0043 | 1 | 10 | peristalsis |
GO:0021559 | 0.0047 | 270.2 | 0.0047 | 1 | 11 | trigeminal nerve development |
GO:0002281 | 0.0052 | 245.6212 | 0.0052 | 1 | 12 | macrophage activation involved in immune response |
GO:0016998 | 0.0052 | 245.6212 | 0.0052 | 1 | 12 | cell wall macromolecule catabolic process |
GO:0031223 | 0.0052 | 245.6212 | 0.0052 | 1 | 12 | auditory behavior |
GO:0035112 | 0.0056 | 225.1389 | 0.0056 | 1 | 13 | genitalia morphogenesis |
GO:0071360 | 0.006 | 207.8077 | 0.006 | 1 | 14 | cellular response to exogenous dsRNA |
GO:0071554 | 0.006 | 207.8077 | 0.006 | 1 | 14 | cell wall organization or biogenesis |
GO:0008595 | 0.0065 | 192.9524 | 0.0065 | 1 | 15 | anterior/posterior axis specification, embryo |
GO:0035458 | 0.0065 | 192.9524 | 0.0065 | 1 | 15 | cellular response to interferon-beta |
GO:0009605 | 0.0066 | 9.1817 | 0.889 | 4 | 2061 | response to external stimulus |
GO:0002710 | 0.0077 | 158.8725 | 0.0078 | 1 | 18 | negative regulation of T cell mediated immunity |
GO:0007350 | 0.0077 | 158.8725 | 0.0078 | 1 | 18 | blastoderm segmentation |
GO:0097094 | 0.0077 | 158.8725 | 0.0078 | 1 | 18 | craniofacial suture morphogenesis |
GO:1903037 | 0.0079 | 19.6272 | 0.1406 | 2 | 326 | regulation of leukocyte cell-cell adhesion |
GO:0035743 | 0.0082 | 150.037 | 0.0082 | 1 | 19 | CD4-positive, alpha-beta T cell cytokine production |
GO:0033141 | 0.009 | 135.0167 | 0.0091 | 1 | 21 | positive regulation of peptidyl-serine phosphorylation of STAT protein |
GO:0002724 | 0.0095 | 128.5794 | 0.0095 | 1 | 22 | regulation of T cell cytokine production |
GO:0090103 | 0.0099 | 122.7273 | 0.0099 | 1 | 23 | cochlea morphogenesis |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0002263 | 2e-04 | 23.6895 | 0.3258 | 4 | 661 | cell activation involved in immune response |
GO:0002275 | 0.001 | 23.372 | 0.2188 | 3 | 507 | myeloid cell activation involved in immune response |
GO:0050868 | 0.001 | 55.9896 | 0.0483 | 2 | 98 | negative regulation of T cell activation |
GO:0043312 | 0.0012 | 20.3754 | 0.2302 | 3 | 467 | neutrophil degranulation |
GO:0042119 | 0.0013 | 19.8897 | 0.2356 | 3 | 478 | neutrophil activation |
GO:0071626 | 0.0015 | 1158.5 | 0.0015 | 1 | 3 | mastication |
GO:0098583 | 0.0015 | 1158.5 | 0.0015 | 1 | 3 | learned vocalization behavior |
GO:1905747 | 0.0015 | 1158.5 | 0.0015 | 1 | 3 | negative regulation of saliva secretion |
GO:1905748 | 0.0015 | 1158.5 | 0.0015 | 1 | 3 | hard palate morphogenesis |
GO:0002444 | 0.0017 | 18.1165 | 0.2578 | 3 | 523 | myeloid leukocyte mediated immunity |
GO:2000552 | 0.002 | 772.2857 | 0.002 | 1 | 4 | negative regulation of T-helper 2 cell cytokine production |
GO:0002695 | 0.0023 | 36.449 | 0.0734 | 2 | 149 | negative regulation of leukocyte activation |
GO:0022408 | 0.0023 | 35.9553 | 0.0744 | 2 | 151 | negative regulation of cell-cell adhesion |
GO:0007356 | 0.0025 | 579.1786 | 0.0025 | 1 | 5 | thorax and anterior abdomen determination |
GO:0021650 | 0.0025 | 579.1786 | 0.0025 | 1 | 5 | vestibulocochlear nerve formation |
GO:1901078 | 0.0025 | 579.1786 | 0.0025 | 1 | 5 | negative regulation of relaxation of muscle |
GO:0060348 | 0.0032 | 30.2147 | 0.0882 | 2 | 179 | bone development |
GO:0045343 | 0.0034 | 386.0714 | 0.0035 | 1 | 7 | regulation of MHC class I biosynthetic process |
GO:0046903 | 0.0038 | 9.8357 | 0.7399 | 4 | 1501 | secretion |
GO:0045321 | 0.0039 | 15.537 | 0.3638 | 3 | 975 | leukocyte activation |
GO:0045055 | 0.0039 | 13.1856 | 0.3495 | 3 | 709 | regulated exocytosis |
GO:0050896 | 0.0043 | Inf | 4.0446 | 8 | 8205 | response to stimulus |
GO:0048705 | 0.0044 | 25.7874 | 0.103 | 2 | 209 | skeletal system morphogenesis |
GO:0021562 | 0.0044 | 289.5179 | 0.0044 | 1 | 9 | vestibulocochlear nerve development |
GO:0006959 | 0.0048 | 24.6991 | 0.1075 | 2 | 218 | humoral immune response |
GO:0030432 | 0.0049 | 257.3333 | 0.0049 | 1 | 10 | peristalsis |
GO:0021559 | 0.0054 | 231.5857 | 0.0054 | 1 | 11 | trigeminal nerve development |
GO:0042742 | 0.0057 | 22.5777 | 0.1173 | 2 | 238 | defense response to bacterium |
GO:0002281 | 0.0059 | 210.5195 | 0.0059 | 1 | 12 | macrophage activation involved in immune response |
GO:0016998 | 0.0059 | 210.5195 | 0.0059 | 1 | 12 | cell wall macromolecule catabolic process |
GO:0031223 | 0.0059 | 210.5195 | 0.0059 | 1 | 12 | auditory behavior |
GO:0035112 | 0.0064 | 192.9643 | 0.0064 | 1 | 13 | genitalia morphogenesis |
GO:0071360 | 0.0069 | 178.1099 | 0.0069 | 1 | 14 | cellular response to exogenous dsRNA |
GO:0071554 | 0.0069 | 178.1099 | 0.0069 | 1 | 14 | cell wall organization or biogenesis |
GO:0008595 | 0.0074 | 165.3776 | 0.0074 | 1 | 15 | anterior/posterior axis specification, embryo |
GO:0035458 | 0.0074 | 165.3776 | 0.0074 | 1 | 15 | cellular response to interferon-beta |
GO:0002710 | 0.0088 | 136.1681 | 0.0089 | 1 | 18 | negative regulation of T cell mediated immunity |
GO:0007350 | 0.0088 | 136.1681 | 0.0089 | 1 | 18 | blastoderm segmentation |
GO:0097094 | 0.0088 | 136.1681 | 0.0089 | 1 | 18 | craniofacial suture morphogenesis |
GO:0035743 | 0.0093 | 128.5952 | 0.0094 | 1 | 19 | CD4-positive, alpha-beta T cell cytokine production |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0006614 | 4e-04 | 96.0655 | 0.0318 | 2 | 86 | SRP-dependent cotranslational protein targeting to membrane |
GO:0072599 | 5e-04 | 83.1237 | 0.0366 | 2 | 99 | establishment of protein localization to endoplasmic reticulum |
GO:0000184 | 7e-04 | 72.5766 | 0.0418 | 2 | 113 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
GO:0006612 | 0.0013 | 52.8651 | 0.0569 | 2 | 154 | protein targeting to membrane |
GO:0019083 | 0.0016 | 47.497 | 0.0632 | 2 | 171 | viral transcription |
GO:0006413 | 0.0017 | 46.3873 | 0.0647 | 2 | 175 | translational initiation |
GO:0043043 | 0.0021 | 19.3041 | 0.2965 | 3 | 802 | peptide biosynthetic process |
GO:0031424 | 0.0028 | 35.7121 | 0.0836 | 2 | 226 | keratinization |
GO:0006364 | 0.0033 | 32.8807 | 0.0906 | 2 | 245 | rRNA processing |
GO:0043603 | 0.0053 | 13.7885 | 0.4067 | 3 | 1100 | cellular amide metabolic process |
GO:0006402 | 0.0058 | 24.4585 | 0.1209 | 2 | 327 | mRNA catabolic process |
GO:0009913 | 0.0065 | 22.8761 | 0.129 | 2 | 349 | epidermal cell differentiation |
GO:0043588 | 0.0088 | 19.4791 | 0.1508 | 2 | 408 | skin development |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0002517 | 0.003 | 491.3333 | 0.003 | 1 | 12 | T cell tolerance induction |
GO:0030511 | 0.0059 | 234.8116 | 0.0059 | 1 | 24 | positive regulation of transforming growth factor beta receptor signaling pathway |
GO:0033198 | 0.0074 | 186.1609 | 0.0074 | 1 | 30 | response to ATP |
GO:0048536 | 0.0088 | 154.1905 | 0.0089 | 1 | 36 | spleen development |
GO:0031670 | 0.0096 | 141.9912 | 0.0096 | 1 | 39 | cellular response to nutrient |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0060044 | 0.0033 | 476.7353 | 0.0033 | 1 | 18 | negative regulation of cardiac muscle cell proliferation |
GO:0071800 | 0.0039 | 405.15 | 0.0039 | 1 | 21 | podosome assembly |
GO:0061117 | 0.0042 | 368.2727 | 0.0043 | 1 | 23 | negative regulation of heart growth |
GO:0055026 | 0.0059 | 261.2097 | 0.0059 | 1 | 32 | negative regulation of cardiac muscle tissue development |
GO:0048635 | 0.0092 | 165.0714 | 0.0092 | 1 | 50 | negative regulation of muscle organ development |
GO:1901862 | 0.0092 | 165.0714 | 0.0092 | 1 | 50 | negative regulation of muscle tissue development |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0070488 | 0 | Inf | 9e-04 | 2 | 2 | neutrophil aggregation |
GO:0032119 | 0 | 648.48 | 0.0052 | 2 | 12 | sequestering of zinc ion |
GO:0002523 | 0 | 540.3333 | 0.006 | 2 | 14 | leukocyte migration involved in inflammatory response |
GO:0055069 | 1e-04 | 249.1692 | 0.0121 | 2 | 28 | zinc ion homeostasis |
GO:0050832 | 1e-04 | 174.973 | 0.0168 | 2 | 39 | defense response to fungus |
GO:2001244 | 2e-04 | 124.3846 | 0.0233 | 2 | 54 | positive regulation of intrinsic apoptotic signaling pathway |
GO:0032602 | 4e-04 | 87.2865 | 0.0328 | 2 | 76 | chemokine production |
GO:0006919 | 5e-04 | 83.8701 | 0.0341 | 2 | 79 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
GO:0030593 | 6e-04 | 75.0512 | 0.038 | 2 | 88 | neutrophil chemotaxis |
GO:0019730 | 7e-04 | 70.1304 | 0.0405 | 2 | 94 | antimicrobial humoral response |
GO:0046916 | 7e-04 | 70.1304 | 0.0405 | 2 | 94 | cellular transition metal ion homeostasis |
GO:0043312 | 8e-04 | 25.4709 | 0.2014 | 3 | 467 | neutrophil degranulation |
GO:0042119 | 8e-04 | 24.8637 | 0.2062 | 3 | 478 | neutrophil activation |
GO:0035606 | 9e-04 | 2703.5 | 9e-04 | 1 | 2 | peptidyl-cysteine S-trans-nitrosylation |
GO:0050729 | 9e-04 | 59.6815 | 0.0474 | 2 | 110 | positive regulation of inflammatory response |
GO:0002275 | 0.001 | 22.8285 | 0.2239 | 3 | 519 | myeloid cell activation involved in immune response |
GO:0002444 | 0.0011 | 22.6471 | 0.2256 | 3 | 523 | myeloid leukocyte mediated immunity |
GO:0097530 | 0.0011 | 53.6733 | 0.0526 | 2 | 122 | granulocyte migration |
GO:2001056 | 0.0012 | 52.3545 | 0.0539 | 2 | 125 | positive regulation of cysteine-type endopeptidase activity |
GO:0002224 | 0.0012 | 51.5104 | 0.0548 | 2 | 127 | toll-like receptor signaling pathway |
GO:0051092 | 0.0013 | 49.9008 | 0.0565 | 2 | 131 | positive regulation of NF-kappaB transcription factor activity |
GO:0043065 | 0.0015 | 20.1188 | 0.2528 | 3 | 586 | positive regulation of apoptotic process |
GO:0030307 | 0.0017 | 43.4432 | 0.0647 | 2 | 150 | positive regulation of cell growth |
GO:0010942 | 0.0019 | 18.4098 | 0.2752 | 3 | 638 | positive regulation of cell death |
GO:0002263 | 0.0021 | 17.7401 | 0.2851 | 3 | 661 | cell activation involved in immune response |
GO:0010952 | 0.0021 | 38.9261 | 0.072 | 2 | 167 | positive regulation of peptidase activity |
GO:0045055 | 0.0025 | 16.483 | 0.3058 | 3 | 709 | regulated exocytosis |
GO:0071947 | 0.0026 | 540.5667 | 0.0026 | 1 | 6 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process |
GO:0030595 | 0.003 | 32.5381 | 0.0858 | 2 | 199 | leukocyte chemotaxis |
GO:0043281 | 0.003 | 32.5381 | 0.0858 | 2 | 199 | regulation of cysteine-type endopeptidase activity involved in apoptotic process |
GO:0018119 | 0.0037 | 360.2667 | 0.0037 | 1 | 10 | peptidyl-cysteine S-nitrosylation |
GO:0042742 | 0.0043 | 27.0949 | 0.1027 | 2 | 238 | defense response to bacterium |
GO:0002758 | 0.0055 | 23.8119 | 0.1165 | 2 | 270 | innate immune response-activating signal transduction |
GO:0051235 | 0.0063 | 22.1306 | 0.1251 | 2 | 290 | maintenance of location |
GO:0060397 | 0.0065 | 192.9524 | 0.0065 | 1 | 15 | JAK-STAT cascade involved in growth hormone signaling pathway |
GO:0045089 | 0.0081 | 19.3228 | 0.1428 | 2 | 331 | positive regulation of innate immune response |
GO:0002544 | 0.009 | 135.0167 | 0.0091 | 1 | 21 | chronic inflammatory response |
GO:0007159 | 0.0094 | 17.9299 | 0.1536 | 2 | 356 | leukocyte cell-cell adhesion |
GO:0045321 | 0.0094 | 10.1033 | 0.4848 | 3 | 1124 | leukocyte activation |
GO:0071378 | 0.0099 | 122.7273 | 0.0099 | 1 | 23 | cellular response to growth hormone stimulus |
GO:2001233 | 0.0099 | 17.3775 | 0.1583 | 2 | 367 | regulation of apoptotic signaling pathway |
GO:0051090 | 0.01 | 17.329 | 0.1587 | 2 | 368 | regulation of DNA binding transcription factor activity |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0070475 | 0 | 661.7551 | 0.005 | 2 | 9 | rRNA base methylation |
GO:0030593 | 0 | 94.9118 | 0.0488 | 3 | 88 | neutrophil chemotaxis |
GO:0097530 | 0 | 67.6513 | 0.0677 | 3 | 122 | granulocyte migration |
GO:0000154 | 2e-04 | 136.0168 | 0.02 | 2 | 36 | rRNA modification |
GO:0060326 | 3e-04 | 31.0564 | 0.1442 | 3 | 260 | cell chemotaxis |
GO:0048247 | 4e-04 | 82.4694 | 0.0322 | 2 | 58 | lymphocyte chemotaxis |
GO:0001510 | 5e-04 | 76.9524 | 0.0344 | 2 | 62 | RNA methylation |
GO:0002548 | 5e-04 | 76.9524 | 0.0344 | 2 | 62 | monocyte chemotaxis |
GO:0070098 | 8e-04 | 59.1282 | 0.0444 | 2 | 80 | chemokine-mediated signaling pathway |
GO:0071347 | 0.0011 | 52.3766 | 0.0499 | 2 | 90 | cellular response to interleukin-1 |
GO:0035606 | 0.0011 | 2027.375 | 0.0011 | 1 | 2 | peptidyl-cysteine S-trans-nitrosylation |
GO:0070488 | 0.0011 | 2027.375 | 0.0011 | 1 | 2 | neutrophil aggregation |
GO:0055076 | 0.0019 | 38.6579 | 0.0671 | 2 | 121 | transition metal ion homeostasis |
GO:0035821 | 0.0026 | 33.2961 | 0.0776 | 2 | 140 | modification of morphology or physiology of other organism |
GO:0071346 | 0.0026 | 33.2961 | 0.0776 | 2 | 140 | cellular response to interferon-gamma |
GO:0042330 | 0.003 | 14.0341 | 0.3111 | 3 | 561 | taxis |
GO:2000503 | 0.0033 | 405.375 | 0.0033 | 1 | 6 | positive regulation of natural killer cell chemotaxis |
GO:0070374 | 0.0048 | 23.8512 | 0.1076 | 2 | 194 | positive regulation of ERK1 and ERK2 cascade |
GO:0009636 | 0.0057 | 21.8879 | 0.117 | 2 | 211 | response to toxic substance |
GO:0051345 | 0.0057 | 10.971 | 0.3937 | 3 | 710 | positive regulation of hydrolase activity |
GO:0017014 | 0.0066 | 184.1932 | 0.0067 | 1 | 12 | protein nitrosylation |
GO:0032119 | 0.0066 | 184.1932 | 0.0067 | 1 | 12 | sequestering of zinc ion |
GO:0043922 | 0.0066 | 184.1932 | 0.0067 | 1 | 12 | negative regulation by host of viral transcription |
GO:0002523 | 0.0077 | 155.8365 | 0.0078 | 1 | 14 | leukocyte migration involved in inflammatory response |
GO:0038092 | 0.0077 | 155.8365 | 0.0078 | 1 | 14 | nodal signaling pathway |
GO:0045087 | 0.0091 | 9.2126 | 0.4647 | 3 | 838 | innate immune response |
GO:0032103 | 0.0093 | 16.9421 | 0.1503 | 2 | 271 | positive regulation of response to external stimulus |
GO:0071356 | 0.0093 | 16.9421 | 0.1503 | 2 | 271 | cellular response to tumor necrosis factor |
GO:0016072 | 0.0098 | 16.4446 | 0.1547 | 2 | 279 | rRNA metabolic process |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0008201 | 5e-04 | 23.8496 | 0.1561 | 3 | 158 | heparin binding |
GO:0004252 | 6e-04 | 21.2202 | 0.1749 | 3 | 177 | serine-type endopeptidase activity |
GO:0017171 | 0.001 | 17.888 | 0.2065 | 3 | 209 | serine hydrolase activity |
GO:0008233 | 0.0024 | 8.6522 | 0.5969 | 4 | 604 | peptidase activity |
GO:1903231 | 0.0053 | 21.055 | 0.1097 | 2 | 111 | mRNA binding involved in posttranscriptional gene silencing |
GO:0004519 | 0.0061 | 19.4383 | 0.1186 | 2 | 120 | endonuclease activity |
GO:0015643 | 0.0098 | 119.7407 | 0.0099 | 1 | 10 | toxic substance binding |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0008201 | 5e-04 | 23.8496 | 0.1561 | 3 | 158 | heparin binding |
GO:0004252 | 6e-04 | 21.2202 | 0.1749 | 3 | 177 | serine-type endopeptidase activity |
GO:0017171 | 0.001 | 17.888 | 0.2065 | 3 | 209 | serine hydrolase activity |
GO:0004968 | 0.002 | 1078.2 | 0.002 | 1 | 2 | gonadotropin-releasing hormone receptor activity |
GO:0008233 | 0.0024 | 8.6522 | 0.5969 | 4 | 604 | peptidase activity |
GO:1903231 | 0.0053 | 21.055 | 0.1097 | 2 | 111 | mRNA binding involved in posttranscriptional gene silencing |
GO:0015643 | 0.0098 | 119.7407 | 0.0099 | 1 | 10 | toxic substance binding |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0005216 | 0.0024 | 5.982 | 0.9482 | 5 | 404 | ion channel activity |
GO:0017080 | 0.0027 | 28.8907 | 0.0775 | 2 | 33 | sodium channel regulator activity |
GO:0005547 | 0.0029 | 27.9861 | 0.0798 | 2 | 34 | phosphatidylinositol-3,4,5-trisphosphate binding |
GO:0022843 | 0.0034 | 10.902 | 0.3028 | 3 | 129 | voltage-gated cation channel activity |
GO:0015267 | 0.0036 | 5.4359 | 1.0398 | 5 | 443 | channel activity |
GO:0030366 | 0.0047 | 436.5135 | 0.0047 | 1 | 2 | molybdopterin synthase activity |
GO:0005544 | 0.0048 | 21.3095 | 0.1033 | 2 | 44 | calcium-dependent phospholipid binding |
GO:0004663 | 0.007 | 218.2432 | 0.007 | 1 | 3 | Rab geranylgeranyltransferase activity |
GO:0005250 | 0.007 | 218.2432 | 0.007 | 1 | 3 | A-type (transient outward) potassium channel activity |
GO:0043120 | 0.007 | 218.2432 | 0.007 | 1 | 3 | tumor necrosis factor binding |
GO:0022832 | 0.0096 | 7.3978 | 0.4413 | 3 | 188 | voltage-gated channel activity |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0017080 | 0.0014 | 41.631 | 0.055 | 2 | 33 | sodium channel regulator activity |
GO:0005547 | 0.0015 | 40.3275 | 0.0567 | 2 | 34 | phosphatidylinositol-3,4,5-trisphosphate binding |
GO:0005544 | 0.0024 | 30.7067 | 0.0734 | 2 | 44 | calcium-dependent phospholipid binding |
GO:0005216 | 0.0043 | 6.8535 | 0.6737 | 4 | 404 | ion channel activity |
GO:0004663 | 0.005 | 310.7885 | 0.005 | 1 | 3 | Rab geranylgeranyltransferase activity |
GO:0005250 | 0.005 | 310.7885 | 0.005 | 1 | 3 | A-type (transient outward) potassium channel activity |
GO:0015267 | 0.0059 | 6.2292 | 0.7388 | 4 | 443 | channel activity |
GO:0046923 | 0.0083 | 155.375 | 0.0083 | 1 | 5 | ER retention sequence binding |
GO:0008318 | 0.01 | 124.2923 | 0.01 | 1 | 6 | protein prenyltransferase activity |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0061750 | 7e-04 | Inf | 7e-04 | 1 | 1 | acid sphingomyelin phosphodiesterase activity |
GO:0005277 | 0.0022 | 735.2727 | 0.0022 | 1 | 3 | acetylcholine transmembrane transporter activity |
GO:0038036 | 0.0059 | 210.013 | 0.0059 | 1 | 8 | sphingosine-1-phosphate receptor activity |
GO:0051378 | 0.0074 | 163.3232 | 0.0074 | 1 | 10 | serotonin binding |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0051378 | 1e-04 | 237.6912 | 0.0117 | 2 | 10 | serotonin binding |
GO:0043565 | 1e-04 | 8.9547 | 1.1689 | 7 | 996 | sequence-specific DNA binding |
GO:0004861 | 1e-04 | 190.1294 | 0.0141 | 2 | 12 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
GO:0001227 | 1e-04 | 19.7904 | 0.257 | 4 | 219 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding |
GO:0004993 | 3e-04 | 100.0124 | 0.0246 | 2 | 21 | G-protein coupled serotonin receptor activity |
GO:0061750 | 0.0012 | Inf | 0.0012 | 1 | 1 | acid sphingomyelin phosphodiesterase activity |
GO:0003700 | 0.0018 | 5.8904 | 1.386 | 6 | 1181 | DNA binding transcription factor activity |
GO:0008013 | 0.0034 | 26.3056 | 0.0868 | 2 | 74 | beta-catenin binding |
GO:0005277 | 0.0035 | 449.1389 | 0.0035 | 1 | 3 | acetylcholine transmembrane transporter activity |
GO:0090722 | 0.0047 | 299.4074 | 0.0047 | 1 | 4 | receptor-receptor interaction |
GO:0030594 | 0.005 | 21.2584 | 0.1068 | 2 | 91 | neurotransmitter receptor activity |
GO:0004860 | 0.0052 | 20.7886 | 0.1091 | 2 | 93 | protein kinase inhibitor activity |
GO:0030284 | 0.0059 | 224.5417 | 0.0059 | 1 | 5 | estrogen receptor activity |
GO:0004857 | 0.0093 | 7.8765 | 0.4448 | 3 | 379 | enzyme inhibitor activity |
GO:0038036 | 0.0094 | 128.2857 | 0.0094 | 1 | 8 | sphingosine-1-phosphate receptor activity |
NA. |
n/a |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0035757 | 0.0011 | Inf | 0.0011 | 1 | 1 | chemokine (C-C motif) ligand 19 binding |
GO:0035758 | 0.0011 | Inf | 0.0011 | 1 | 1 | chemokine (C-C motif) ligand 21 binding |
GO:0038117 | 0.0011 | Inf | 0.0011 | 1 | 1 | C-C motif chemokine 19 receptor activity |
GO:0038121 | 0.0011 | Inf | 0.0011 | 1 | 1 | C-C motif chemokine 21 receptor activity |
GO:0038100 | 0.0022 | 951.2353 | 0.0022 | 1 | 2 | nodal binding |
GO:0070405 | 0.0024 | 31.4609 | 0.0734 | 2 | 66 | ammonium ion binding |
GO:0005111 | 0.0033 | 475.5882 | 0.0033 | 1 | 3 | type 2 fibroblast growth factor receptor binding |
GO:0005277 | 0.0033 | 475.5882 | 0.0033 | 1 | 3 | acetylcholine transmembrane transporter activity |
GO:0005105 | 0.0044 | 317.0392 | 0.0044 | 1 | 4 | type 1 fibroblast growth factor receptor binding |
GO:0090722 | 0.0044 | 317.0392 | 0.0044 | 1 | 4 | receptor-receptor interaction |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0032394 | 0 | Inf | 6e-04 | 2 | 2 | MHC class Ib receptor activity |
GO:0042288 | 0 | 673.7083 | 0.0056 | 2 | 18 | MHC class I protein binding |
GO:0005133 | 3e-04 | Inf | 3e-04 | 1 | 1 | interferon-gamma receptor binding |
GO:0004522 | 0.0012 | 1348.5 | 0.0012 | 1 | 4 | ribonuclease A activity |
GO:0030246 | 0.0025 | 41.155 | 0.0803 | 2 | 260 | carbohydrate binding |
GO:0099600 | 0.0038 | 18.4159 | 0.3774 | 3 | 1222 | transmembrane receptor activity |
GO:0038023 | 0.0044 | 17.4965 | 0.3956 | 3 | 1281 | signaling receptor activity |
GO:0005102 | 0.0062 | 15.2778 | 0.4478 | 3 | 1450 | receptor binding |
GO:0004993 | 0.0065 | 202.0625 | 0.0065 | 1 | 21 | G-protein coupled serotonin receptor activity |
GO:0016894 | 0.0068 | 192.4286 | 0.0068 | 1 | 22 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters |
GO:0060089 | 0.0074 | 14.3366 | 0.4744 | 3 | 1536 | molecular transducer activity |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0008173 | 5e-04 | 73.2955 | 0.0352 | 2 | 57 | RNA methyltransferase activity |
GO:0008757 | 0.0036 | 27.4555 | 0.0914 | 2 | 148 | S-adenosylmethionine-dependent methyltransferase activity |
GO:0046703 | 0.0055 | 224.6111 | 0.0056 | 1 | 9 | natural killer cell lectin-like receptor binding |
GO:0016741 | 0.0074 | 18.7406 | 0.1328 | 2 | 215 | transferase activity, transferring one-carbon groups |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0004984 | 2e-04 | 42.9783 | 0.1375 | 3 | 371 | olfactory receptor activity |
GO:0004930 | 0.002 | 19.7222 | 0.2905 | 3 | 784 | G-protein coupled receptor activity |
GO:0005344 | 0.0052 | 248.7846 | 0.0052 | 1 | 14 | oxygen carrier activity |
GO:0099600 | 0.0072 | 12.2765 | 0.4529 | 3 | 1222 | transmembrane receptor activity |
GO:0038023 | 0.0082 | 11.6635 | 0.4747 | 3 | 1281 | signaling receptor activity |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0042056 | 0 | 299.2037 | 0.0107 | 2 | 29 | chemoattractant activity |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0035662 | 0.0015 | 1155.7143 | 0.0015 | 1 | 3 | Toll-like receptor 4 binding |
GO:0050544 | 0.0025 | 577.7857 | 0.0025 | 1 | 5 | arachidonic acid binding |
GO:0036041 | 0.0054 | 231.0286 | 0.0054 | 1 | 11 | long-chain fatty acid binding |
GO:0050786 | 0.0054 | 231.0286 | 0.0054 | 1 | 11 | RAGE receptor binding |
GO:0022841 | 0.0079 | 153.9714 | 0.0079 | 1 | 16 | potassium ion leak channel activity |
GO:0022842 | 0.0094 | 128.2857 | 0.0094 | 1 | 19 | narrow pore channel activity |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0008811 | 4e-04 | Inf | 4e-04 | 1 | 1 | chloramphenicol O-acetyltransferase activity |
GO:0003796 | 0.0048 | 269.5333 | 0.0048 | 1 | 13 | lysozyme activity |
GO:0005132 | 0.0063 | 202.1 | 0.0063 | 1 | 17 | type I interferon receptor binding |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0008811 | 4e-04 | Inf | 4e-04 | 1 | 1 | chloramphenicol O-acetyltransferase activity |
GO:0003796 | 0.0056 | 224.5972 | 0.0056 | 1 | 13 | lysozyme activity |
GO:0005132 | 0.0073 | 168.4062 | 0.0074 | 1 | 17 | type I interferon receptor binding |
GO:0017134 | 0.0099 | 122.4318 | 0.0099 | 1 | 23 | fibroblast growth factor binding |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0035717 | 9e-04 | Inf | 9e-04 | 1 | 1 | chemokine (C-C motif) ligand 7 binding |
GO:0071791 | 0.0017 | 1244.2308 | 0.0017 | 1 | 2 | chemokine (C-C motif) ligand 5 binding |
GO:0004698 | 0.0035 | 414.6923 | 0.0035 | 1 | 4 | calcium-dependent protein kinase C activity |
GO:0031726 | 0.0043 | 311 | 0.0043 | 1 | 5 | CCR1 chemokine receptor binding |
GO:0001228 | 0.0044 | 10.9243 | 0.3433 | 3 | 397 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding |
GO:0031730 | 0.0052 | 248.7846 | 0.0052 | 1 | 6 | CCR5 chemokine receptor binding |
GO:0003680 | 0.0069 | 177.6813 | 0.0069 | 1 | 8 | AT DNA binding |
GO:0072542 | 0.0069 | 177.6813 | 0.0069 | 1 | 8 | protein phosphatase activator activity |
GO:0102991 | 0.0069 | 177.6813 | 0.0069 | 1 | 8 | myristoyl-CoA hydrolase activity |
GO:0042975 | 0.0078 | 155.4615 | 0.0078 | 1 | 9 | peroxisome proliferator activated receptor binding |
GO:0016004 | 0.0095 | 124.3538 | 0.0095 | 1 | 11 | phospholipase activator activity |
GO:0016290 | 0.0095 | 124.3538 | 0.0095 | 1 | 11 | palmitoyl-CoA hydrolase activity |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0035717 | 9e-04 | Inf | 9e-04 | 1 | 1 | chemokine (C-C motif) ligand 7 binding |
GO:0003924 | 0.0014 | 16.5656 | 0.2292 | 3 | 265 | GTPase activity |
GO:0071791 | 0.0017 | 1244.2308 | 0.0017 | 1 | 2 | chemokine (C-C motif) ligand 5 binding |
GO:0005525 | 0.0029 | 12.6646 | 0.2975 | 3 | 344 | GTP binding |
GO:0001883 | 0.003 | 12.4777 | 0.3018 | 3 | 349 | purine nucleoside binding |
GO:0032549 | 0.0031 | 12.4409 | 0.3027 | 3 | 350 | ribonucleoside binding |
GO:0019001 | 0.0034 | 12.016 | 0.313 | 3 | 362 | guanyl nucleotide binding |
GO:0004698 | 0.0035 | 414.6923 | 0.0035 | 1 | 4 | calcium-dependent protein kinase C activity |
GO:0005200 | 0.0035 | 26.5264 | 0.0891 | 2 | 103 | structural constituent of cytoskeleton |
GO:0031726 | 0.0043 | 311 | 0.0043 | 1 | 5 | CCR1 chemokine receptor binding |
GO:0031730 | 0.0052 | 248.7846 | 0.0052 | 1 | 6 | CCR5 chemokine receptor binding |
GO:0072542 | 0.0069 | 177.6813 | 0.0069 | 1 | 8 | protein phosphatase activator activity |
GO:0102991 | 0.0069 | 177.6813 | 0.0069 | 1 | 8 | myristoyl-CoA hydrolase activity |
GO:0008047 | 0.008 | 8.7123 | 0.4272 | 3 | 494 | enzyme activator activity |
GO:0016004 | 0.0095 | 124.3538 | 0.0095 | 1 | 11 | phospholipase activator activity |
GO:0016290 | 0.0095 | 124.3538 | 0.0095 | 1 | 11 | palmitoyl-CoA hydrolase activity |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0005544 | 4e-04 | 85.381 | 0.0299 | 2 | 44 | calcium-dependent phospholipid binding |
GO:0005146 | 0.0014 | 1617.8 | 0.0014 | 1 | 2 | leukemia inhibitory factor receptor binding |
GO:0001135 | 0.0054 | 231.0286 | 0.0054 | 1 | 8 | transcription factor activity, RNA polymerase II transcription factor recruiting |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0003735 | 0 | 109.0952 | 0.0556 | 3 | 150 | structural constituent of ribosome |
GO:0017134 | 0.0085 | 146.9273 | 0.0085 | 1 | 23 | fibroblast growth factor binding |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0043208 | 0.002 | 770.4286 | 0.002 | 1 | 8 | glycosphingolipid binding |
GO:0004861 | 0.003 | 490.1515 | 0.003 | 1 | 12 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0003735 | 0 | 78.9803 | 0.1112 | 5 | 150 | structural constituent of ribosome |
GO:0019843 | 8e-04 | 59.7185 | 0.0415 | 2 | 56 | rRNA binding |
GO:0003676 | 0.002 | 6.3824 | 2.867 | 8 | 3868 | nucleic acid binding |
GO:1903231 | 0.0029 | 29.4844 | 0.0823 | 2 | 111 | mRNA binding involved in posttranscriptional gene silencing |
GO:0008142 | 0.0037 | 367.5909 | 0.0037 | 1 | 5 | oxysterol binding |
GO:0003729 | 0.0053 | 22.1927 | 0.1126 | 2 | 181 | mRNA binding |
GO:0016175 | 0.0067 | 183.75 | 0.0067 | 1 | 9 | superoxide-generating NADPH oxidase activity |
GO:0016176 | 0.0074 | 163.3232 | 0.0074 | 1 | 10 | superoxide-generating NADPH oxidase activator activity |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0016175 | 0.0011 | 2022.5 | 0.0011 | 1 | 9 | superoxide-generating NADPH oxidase activity |
GO:0016176 | 0.0012 | 1797.6667 | 0.0012 | 1 | 10 | superoxide-generating NADPH oxidase activator activity |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:1903231 | 0 | 89.3 | 0.0548 | 3 | 111 | mRNA binding involved in posttranscriptional gene silencing |
GO:0048030 | 0.002 | 770.4286 | 0.002 | 1 | 4 | disaccharide binding |
GO:0005534 | 0.0025 | 577.7857 | 0.0025 | 1 | 5 | galactose binding |
GO:0030246 | 0.0067 | 20.5736 | 0.1285 | 2 | 260 | carbohydrate binding |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0035662 | 0 | 6472.8 | 0.0013 | 2 | 3 | Toll-like receptor 4 binding |
GO:0050544 | 0 | 2157.3333 | 0.0022 | 2 | 5 | arachidonic acid binding |
GO:0036041 | 0 | 718.8444 | 0.0048 | 2 | 11 | long-chain fatty acid binding |
GO:0050786 | 0 | 718.8444 | 0.0048 | 2 | 11 | RAGE receptor binding |
GO:1901567 | 0 | 307.8476 | 0.0099 | 2 | 23 | fatty acid derivative binding |
GO:0043177 | 0 | 69.0043 | 0.0765 | 3 | 177 | organic acid binding |
GO:0033293 | 3e-04 | 115.1929 | 0.0251 | 2 | 58 | monocarboxylic acid binding |
GO:0004966 | 0.003 | 449.3611 | 0.003 | 1 | 7 | galanin receptor activity |
GO:0008017 | 0.0032 | 31.3314 | 0.0891 | 2 | 206 | microtubule binding |
GO:0005540 | 0.0095 | 128.2698 | 0.0095 | 1 | 22 | hyaluronic acid binding |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0008009 | 3e-04 | 100.2174 | 0.0267 | 2 | 48 | chemokine activity |
GO:0008173 | 4e-04 | 83.7714 | 0.0317 | 2 | 57 | RNA methyltransferase activity |
GO:0038100 | 0.0011 | 2022.5 | 0.0011 | 1 | 2 | nodal binding |
GO:0035662 | 0.0017 | 1011.1875 | 0.0017 | 1 | 3 | Toll-like receptor 4 binding |
GO:0031726 | 0.0028 | 505.5312 | 0.0028 | 1 | 5 | CCR1 chemokine receptor binding |
GO:0050544 | 0.0028 | 505.5312 | 0.0028 | 1 | 5 | arachidonic acid binding |
GO:0008757 | 0.0029 | 31.3796 | 0.0823 | 2 | 148 | S-adenosylmethionine-dependent methyltransferase activity |
GO:0031730 | 0.0033 | 404.4 | 0.0033 | 1 | 6 | CCR5 chemokine receptor binding |
GO:0016741 | 0.0059 | 21.4192 | 0.1195 | 2 | 215 | transferase activity, transferring one-carbon groups |
GO:0036041 | 0.0061 | 202.1375 | 0.0061 | 1 | 11 | long-chain fatty acid binding |
GO:0050786 | 0.0061 | 202.1375 | 0.0061 | 1 | 11 | RAGE receptor binding |
GO:0001664 | 0.0085 | 17.7734 | 0.1434 | 2 | 258 | G-protein coupled receptor binding |
GO:0005126 | 0.0088 | 17.4275 | 0.1462 | 2 | 263 | cytokine receptor binding |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0017176 | 0.0025 | 577.7857 | 0.0025 | 1 | 5 | phosphatidylinositol N-acetylglucosaminyltransferase activity |
GO:0019763 | 0.003 | 462.2 | 0.003 | 1 | 6 | immunoglobulin receptor activity |
GO:0097027 | 0.0039 | 330.102 | 0.004 | 1 | 8 | ubiquitin-protein transferase activator activity |
GO:0019864 | 0.0054 | 231.0286 | 0.0054 | 1 | 11 | IgG binding |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0003727 | 0.0016 | 40.6692 | 0.0594 | 2 | 74 | single-stranded RNA binding |
GO:0004082 | 0.0032 | 449.2778 | 0.0032 | 1 | 4 | bisphosphoglycerate mutase activity |
GO:0046538 | 0.0032 | 449.2778 | 0.0032 | 1 | 4 | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity |
GO:0048248 | 0.004 | 336.9375 | 0.004 | 1 | 5 | CXCR3 chemokine receptor binding |
GO:0043565 | 0.0065 | 6.8033 | 0.7998 | 4 | 996 | sequence-specific DNA binding |
GO:0019957 | 0.0072 | 168.4271 | 0.0072 | 1 | 9 | C-C chemokine binding |
GO:0035925 | 0.0096 | 122.4697 | 0.0096 | 1 | 12 | mRNA 3'-UTR AU-rich region binding |
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GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0098542 | 0 | 14.7731 | 0.5705 | 6 | 463 | defense response to other organism |
GO:0042119 | 0 | 14.3212 | 0.5878 | 6 | 477 | neutrophil activation |
GO:0002275 | 0 | 13.1136 | 0.6396 | 6 | 519 | myeloid cell activation involved in immune response |
GO:0002444 | 0 | 13.0349 | 0.6433 | 6 | 522 | myeloid leukocyte mediated immunity |
GO:0031640 | 0 | 51.8342 | 0.0715 | 3 | 58 | killing of cells of other organism |
GO:0016045 | 1e-04 | 180 | 0.0148 | 2 | 12 | detection of bacterium |
GO:0002263 | 1e-04 | 10.194 | 0.8133 | 6 | 660 | cell activation involved in immune response |
GO:0043312 | 1e-04 | 12.3891 | 0.5376 | 5 | 459 | neutrophil degranulation |
GO:0045055 | 2e-04 | 9.4676 | 0.8725 | 6 | 708 | regulated exocytosis |
GO:0098581 | 2e-04 | 112.4583 | 0.0222 | 2 | 18 | detection of external biotic stimulus |
GO:0035821 | 7e-04 | 20.4033 | 0.175 | 3 | 142 | modification of morphology or physiology of other organism |
GO:0032940 | 9e-04 | 5.842 | 1.6944 | 7 | 1375 | secretion by cell |
GO:0019547 | 0.0012 | Inf | 0.0012 | 1 | 1 | arginine catabolic process to ornithine |
GO:0044356 | 0.0012 | Inf | 0.0012 | 1 | 1 | clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine |
GO:0061015 | 0.0012 | Inf | 0.0012 | 1 | 1 | snRNA import into nucleus |
GO:0070965 | 0.0012 | Inf | 0.0012 | 1 | 1 | positive regulation of neutrophil mediated killing of fungus |
GO:0099046 | 0.0012 | Inf | 0.0012 | 1 | 1 | clearance of foreign intracellular nucleic acids |
GO:1900150 | 0.0012 | Inf | 0.0012 | 1 | 1 | regulation of defense response to fungus |
GO:1904676 | 0.0012 | Inf | 0.0012 | 1 | 1 | negative regulation of somatic stem cell division |
GO:1905175 | 0.0012 | Inf | 0.0012 | 1 | 1 | negative regulation of vascular smooth muscle cell dedifferentiation |
GO:0031343 | 0.0013 | 43.8184 | 0.053 | 2 | 43 | positive regulation of cell killing |
GO:0032964 | 0.0014 | 41.7752 | 0.0555 | 2 | 45 | collagen biosynthetic process |
GO:0043207 | 0.0014 | 7.4697 | 0.886 | 5 | 798 | response to external biotic stimulus |
GO:0002376 | 0.0017 | 6.5914 | 1.4345 | 6 | 1548 | immune system process |
GO:0061844 | 0.0018 | 36.6463 | 0.0628 | 2 | 51 | antimicrobial humoral immune response mediated by antimicrobial peptide |
GO:0045321 | 0.0018 | 5.7965 | 1.3826 | 6 | 1122 | leukocyte activation |
GO:0009620 | 0.0018 | 35.9111 | 0.0641 | 2 | 52 | response to fungus |
GO:0006959 | 0.0023 | 13.067 | 0.2699 | 3 | 219 | humoral immune response |
GO:0010963 | 0.0025 | 853.1053 | 0.0025 | 1 | 2 | regulation of L-arginine import |
GO:0044663 | 0.0025 | 853.1053 | 0.0025 | 1 | 2 | establishment or maintenance of cell type involved in phenotypic switching |
GO:0070949 | 0.0025 | 853.1053 | 0.0025 | 1 | 2 | regulation of neutrophil mediated killing of symbiont cell |
GO:0070960 | 0.0025 | 853.1053 | 0.0025 | 1 | 2 | positive regulation of neutrophil mediated cytotoxicity |
GO:0045087 | 0.0029 | 6.1533 | 1.0327 | 5 | 838 | innate immune response |
GO:0010466 | 0.0033 | 11.5473 | 0.3044 | 3 | 247 | negative regulation of peptidase activity |
GO:0032827 | 0.0037 | 426.5263 | 0.0037 | 1 | 3 | negative regulation of natural killer cell differentiation involved in immune response |
GO:0035879 | 0.0037 | 426.5263 | 0.0037 | 1 | 3 | plasma membrane lactate transport |
GO:0051714 | 0.0037 | 426.5263 | 0.0037 | 1 | 3 | positive regulation of cytolysis in other organism |
GO:0090678 | 0.0037 | 426.5263 | 0.0037 | 1 | 3 | cell dedifferentiation involved in phenotypic switching |
GO:0016192 | 0.004 | 4.3985 | 2.1873 | 7 | 1775 | vesicle-mediated transport |
GO:0019732 | 0.0049 | 284.3333 | 0.0049 | 1 | 4 | antifungal humoral response |
GO:0032792 | 0.0049 | 284.3333 | 0.0049 | 1 | 4 | negative regulation of CREB transcription factor activity |
GO:0090467 | 0.0049 | 284.3333 | 0.0049 | 1 | 4 | arginine import |
GO:2000552 | 0.0049 | 284.3333 | 0.0049 | 1 | 4 | negative regulation of T-helper 2 cell cytokine production |
GO:0050830 | 0.0051 | 21.0784 | 0.1072 | 2 | 87 | defense response to Gram-positive bacterium |
GO:0036446 | 0.0061 | 213.2368 | 0.0062 | 1 | 5 | myofibroblast differentiation |
GO:0060414 | 0.0061 | 213.2368 | 0.0062 | 1 | 5 | aorta smooth muscle tissue morphogenesis |
GO:1902023 | 0.0061 | 213.2368 | 0.0062 | 1 | 5 | L-arginine transport |
GO:1904673 | 0.0061 | 213.2368 | 0.0062 | 1 | 5 | negative regulation of somatic stem cell population maintenance |
GO:2000724 | 0.0061 | 213.2368 | 0.0062 | 1 | 5 | positive regulation of cardiac vascular smooth muscle cell differentiation |
GO:0050896 | 0.0067 | 3.9199 | 10.1084 | 16 | 8203 | response to stimulus |
GO:2000117 | 0.0073 | 17.3754 | 0.1294 | 2 | 105 | negative regulation of cysteine-type endopeptidase activity |
GO:0010269 | 0.0074 | 170.5789 | 0.0074 | 1 | 6 | response to selenium ion |
GO:0015727 | 0.0074 | 170.5789 | 0.0074 | 1 | 6 | lactate transport |
GO:0060336 | 0.0074 | 170.5789 | 0.0074 | 1 | 6 | negative regulation of interferon-gamma-mediated signaling pathway |
GO:0070383 | 0.0074 | 170.5789 | 0.0074 | 1 | 6 | DNA cytosine deamination |
GO:0002697 | 0.0074 | 8.5448 | 0.4079 | 3 | 331 | regulation of immune effector process |
GO:0001816 | 0.0078 | 5.937 | 0.8121 | 4 | 659 | cytokine production |
GO:0070268 | 0.0084 | 16.1151 | 0.1392 | 2 | 113 | cornification |
GO:0009253 | 0.0086 | 142.1404 | 0.0086 | 1 | 7 | peptidoglycan catabolic process |
GO:0009635 | 0.0086 | 142.1404 | 0.0086 | 1 | 7 | response to herbicide |
GO:0010668 | 0.0086 | 142.1404 | 0.0086 | 1 | 7 | ectodermal cell differentiation |
GO:0032815 | 0.0086 | 142.1404 | 0.0086 | 1 | 7 | negative regulation of natural killer cell activation |
GO:0051597 | 0.0086 | 142.1404 | 0.0086 | 1 | 7 | response to methylmercury |
GO:0043313 | 0.0098 | 121.8271 | 0.0099 | 1 | 8 | regulation of neutrophil degranulation |
GO:0043696 | 0.0098 | 121.8271 | 0.0099 | 1 | 8 | dedifferentiation |
GO:0070269 | 0.0098 | 121.8271 | 0.0099 | 1 | 8 | pyroptosis |
GO:1900239 | 0.0098 | 121.8271 | 0.0099 | 1 | 8 | regulation of phenotypic switching |
GO:2000035 | 0.0098 | 121.8271 | 0.0099 | 1 | 8 | regulation of stem cell division |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0008584 | 0.0014 | 15.189 | 0.2243 | 3 | 130 | male gonad development |
GO:0060010 | 0.0017 | Inf | 0.0017 | 1 | 1 | Sertoli cell fate commitment |
GO:0061185 | 0.0017 | Inf | 0.0017 | 1 | 1 | negative regulation of dermatome development |
GO:0061682 | 0.0017 | Inf | 0.0017 | 1 | 1 | seminal vesicle morphogenesis |
GO:2000287 | 0.0017 | Inf | 0.0017 | 1 | 1 | positive regulation of myotome development |
GO:0046661 | 0.0023 | 12.8416 | 0.264 | 3 | 153 | male sex differentiation |
GO:0030850 | 0.003 | 27.6188 | 0.0811 | 2 | 47 | prostate gland development |
GO:2000041 | 0.0034 | 600.037 | 0.0035 | 1 | 2 | negative regulation of planar cell polarity pathway involved in axis elongation |
GO:0060350 | 0.0035 | 25.3579 | 0.088 | 2 | 51 | endochondral bone morphogenesis |
GO:0060348 | 0.0035 | 10.9268 | 0.3088 | 3 | 179 | bone development |
GO:0051094 | 0.0036 | 4.171 | 2.0806 | 7 | 1206 | positive regulation of developmental process |
GO:0043124 | 0.004 | 23.4383 | 0.0949 | 2 | 55 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
GO:0045600 | 0.0043 | 22.5832 | 0.0983 | 2 | 57 | positive regulation of fat cell differentiation |
GO:0045669 | 0.0045 | 22.1786 | 0.1001 | 2 | 58 | positive regulation of osteoblast differentiation |
GO:0061458 | 0.005 | 6.5339 | 0.7022 | 4 | 407 | reproductive system development |
GO:0060741 | 0.0052 | 300 | 0.0052 | 1 | 3 | prostate gland stromal morphogenesis |
GO:0070458 | 0.0052 | 300 | 0.0052 | 1 | 3 | cellular detoxification of nitrogen compound |
GO:1904715 | 0.0052 | 300 | 0.0052 | 1 | 3 | negative regulation of chaperone-mediated autophagy |
GO:1990834 | 0.0052 | 300 | 0.0052 | 1 | 3 | response to odorant |
GO:0045137 | 0.0052 | 9.4575 | 0.3554 | 3 | 206 | development of primary sexual characteristics |
GO:0048705 | 0.0054 | 9.3181 | 0.3606 | 3 | 209 | skeletal system morphogenesis |
GO:0048041 | 0.0066 | 17.9855 | 0.1225 | 2 | 71 | focal adhesion assembly |
GO:0008588 | 0.0069 | 199.9877 | 0.0069 | 1 | 4 | release of cytoplasmic sequestered NF-kappaB |
GO:0018916 | 0.0069 | 199.9877 | 0.0069 | 1 | 4 | nitrobenzene metabolic process |
GO:0042662 | 0.0069 | 199.9877 | 0.0069 | 1 | 4 | negative regulation of mesodermal cell fate specification |
GO:0090244 | 0.0069 | 199.9877 | 0.0069 | 1 | 4 | Wnt signaling pathway involved in somitogenesis |
GO:1905903 | 0.0069 | 199.9877 | 0.0069 | 1 | 4 | negative regulation of mesoderm formation |
GO:0021766 | 0.007 | 17.4767 | 0.1259 | 2 | 73 | hippocampus development |
GO:0043627 | 0.007 | 17.4767 | 0.1259 | 2 | 73 | response to estrogen |
GO:0003151 | 0.0072 | 17.2329 | 0.1277 | 2 | 74 | outflow tract morphogenesis |
GO:0045621 | 0.0083 | 15.9014 | 0.138 | 2 | 80 | positive regulation of lymphocyte differentiation |
GO:0034333 | 0.0085 | 15.6991 | 0.1397 | 2 | 81 | adherens junction assembly |
GO:0060591 | 0.0086 | 149.9815 | 0.0086 | 1 | 5 | chondroblast differentiation |
GO:0061056 | 0.0086 | 149.9815 | 0.0086 | 1 | 5 | sclerotome development |
GO:1904956 | 0.0086 | 149.9815 | 0.0086 | 1 | 5 | regulation of midbrain dopaminergic neuron differentiation |
GO:0045944 | 0.0087 | 3.8841 | 1.8442 | 6 | 1069 | positive regulation of transcription from RNA polymerase II promoter |
GO:0001843 | 0.0094 | 14.9388 | 0.1466 | 2 | 85 | neural tube closure |
GO:0007044 | 0.0098 | 14.5855 | 0.1501 | 2 | 87 | cell-substrate junction assembly |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:2001236 | 2e-04 | 33.2524 | 0.1185 | 3 | 148 | regulation of extrinsic apoptotic signaling pathway |
GO:1902042 | 4e-04 | 86.5401 | 0.0288 | 2 | 36 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
GO:2000351 | 5e-04 | 75.4219 | 0.0328 | 2 | 41 | regulation of endothelial cell apoptotic process |
GO:2001234 | 5e-04 | 24.2712 | 0.161 | 3 | 201 | negative regulation of apoptotic signaling pathway |
GO:0042113 | 6e-04 | 22.4341 | 0.1738 | 3 | 217 | B cell activation |
GO:0002642 | 8e-04 | Inf | 8e-04 | 1 | 1 | positive regulation of immunoglobulin biosynthetic process |
GO:0030887 | 8e-04 | Inf | 8e-04 | 1 | 1 | positive regulation of myeloid dendritic cell activation |
GO:1904155 | 8e-04 | Inf | 8e-04 | 1 | 1 | DN2 thymocyte differentiation |
GO:1904156 | 8e-04 | Inf | 8e-04 | 1 | 1 | DN3 thymocyte differentiation |
GO:0045321 | 0.0013 | 8.449 | 0.8987 | 5 | 1122 | leukocyte activation |
GO:0034021 | 0.0016 | 1351.3333 | 0.0016 | 1 | 2 | response to silicon dioxide |
GO:0036345 | 0.0016 | 1351.3333 | 0.0016 | 1 | 2 | platelet maturation |
GO:0030098 | 0.0018 | 15.2435 | 0.2531 | 3 | 316 | lymphocyte differentiation |
GO:0007166 | 0.002 | 6.0519 | 2.105 | 7 | 2628 | cell surface receptor signaling pathway |
GO:0002377 | 0.0022 | 34.1036 | 0.0705 | 2 | 88 | immunoglobulin production |
GO:1904019 | 0.0023 | 33.3244 | 0.0721 | 2 | 90 | epithelial cell apoptotic process |
GO:0021553 | 0.0024 | 675.625 | 0.0024 | 1 | 3 | olfactory nerve development |
GO:0048388 | 0.0024 | 675.625 | 0.0024 | 1 | 3 | endosomal lumen acidification |
GO:0061368 | 0.0024 | 675.625 | 0.0024 | 1 | 3 | behavioral response to formalin induced pain |
GO:0099566 | 0.0024 | 675.625 | 0.0024 | 1 | 3 | regulation of postsynaptic cytosolic calcium ion concentration |
GO:0030097 | 0.003 | 8.5425 | 0.6456 | 4 | 806 | hemopoiesis |
GO:0030644 | 0.0032 | 450.3889 | 0.0032 | 1 | 4 | cellular chloride ion homeostasis |
GO:0045918 | 0.0032 | 450.3889 | 0.0032 | 1 | 4 | negative regulation of cytolysis |
GO:0046666 | 0.0032 | 450.3889 | 0.0032 | 1 | 4 | retinal cell programmed cell death |
GO:0060474 | 0.0032 | 450.3889 | 0.0032 | 1 | 4 | positive regulation of flagellated sperm motility involved in capacitation |
GO:2001274 | 0.0032 | 450.3889 | 0.0032 | 1 | 4 | negative regulation of glucose import in response to insulin stimulus |
GO:0008219 | 0.0034 | 5.8386 | 1.6677 | 6 | 2082 | cell death |
GO:0006874 | 0.0034 | 12.0794 | 0.3172 | 3 | 396 | cellular calcium ion homeostasis |
GO:0043069 | 0.0035 | 8.1977 | 0.6712 | 4 | 838 | negative regulation of programmed cell death |
GO:0032747 | 0.004 | 337.7708 | 0.004 | 1 | 5 | positive regulation of interleukin-23 production |
GO:0060385 | 0.004 | 337.7708 | 0.004 | 1 | 5 | axonogenesis involved in innervation |
GO:0072679 | 0.004 | 337.7708 | 0.004 | 1 | 5 | thymocyte migration |
GO:0002520 | 0.0043 | 7.6997 | 0.7121 | 4 | 889 | immune system development |
GO:0051240 | 0.0043 | 6.242 | 1.1863 | 5 | 1481 | positive regulation of multicellular organismal process |
GO:0072507 | 0.0046 | 10.8585 | 0.3516 | 3 | 439 | divalent inorganic cation homeostasis |
GO:0051599 | 0.0048 | 270.2 | 0.0048 | 1 | 6 | response to hydrostatic pressure |
GO:0097527 | 0.0048 | 270.2 | 0.0048 | 1 | 6 | necroptotic signaling pathway |
GO:0002684 | 0.0051 | 7.3223 | 0.7465 | 4 | 932 | positive regulation of immune system process |
GO:1902533 | 0.0053 | 7.2477 | 0.7537 | 4 | 941 | positive regulation of intracellular signal transduction |
GO:0050906 | 0.0053 | 10.3225 | 0.3693 | 3 | 461 | detection of stimulus involved in sensory perception |
GO:0030223 | 0.0056 | 225.1528 | 0.0056 | 1 | 7 | neutrophil differentiation |
GO:0048290 | 0.0056 | 225.1528 | 0.0056 | 1 | 7 | isotype switching to IgA isotypes |
GO:0001821 | 0.0064 | 192.9762 | 0.0064 | 1 | 8 | histamine secretion |
GO:0038180 | 0.0064 | 192.9762 | 0.0064 | 1 | 8 | nerve growth factor signaling pathway |
GO:0042045 | 0.0064 | 192.9762 | 0.0064 | 1 | 8 | epithelial fluid transport |
GO:0071316 | 0.0064 | 192.9762 | 0.0064 | 1 | 8 | cellular response to nicotine |
GO:1902715 | 0.0064 | 192.9762 | 0.0064 | 1 | 8 | positive regulation of interferon-gamma secretion |
GO:0050865 | 0.0064 | 9.5884 | 0.3965 | 3 | 495 | regulation of cell activation |
GO:0010623 | 0.0066 | 184.1591 | 0.0067 | 1 | 9 | programmed cell death involved in cell development |
GO:0042221 | 0.0067 | 4.6388 | 3.3377 | 8 | 4167 | response to chemical |
GO:0001766 | 0.0072 | 168.8438 | 0.0072 | 1 | 9 | membrane raft polarization |
GO:0071803 | 0.0072 | 168.8438 | 0.0072 | 1 | 9 | positive regulation of podosome assembly |
GO:0097011 | 0.0072 | 168.8438 | 0.0072 | 1 | 9 | cellular response to granulocyte macrophage colony-stimulating factor stimulus |
GO:2000510 | 0.0072 | 168.8438 | 0.0072 | 1 | 9 | positive regulation of dendritic cell chemotaxis |
GO:0050966 | 0.008 | 150.0741 | 0.008 | 1 | 10 | detection of mechanical stimulus involved in sensory perception of pain |
GO:0051665 | 0.008 | 150.0741 | 0.008 | 1 | 10 | membrane raft localization |
GO:0090331 | 0.0088 | 135.0583 | 0.0088 | 1 | 11 | negative regulation of platelet aggregation |
GO:0007610 | 0.0088 | 8.5136 | 0.4445 | 3 | 555 | behavior |
GO:0055065 | 0.0092 | 8.3568 | 0.4526 | 3 | 565 | metal ion homeostasis |
GO:0043523 | 0.0095 | 15.7563 | 0.1498 | 2 | 187 | regulation of neuron apoptotic process |
GO:0007623 | 0.0096 | 15.6706 | 0.1506 | 2 | 188 | circadian rhythm |
GO:0034116 | 0.0096 | 122.7727 | 0.0096 | 1 | 12 | positive regulation of heterotypic cell-cell adhesion |
GO:0030003 | 0.0099 | 8.1464 | 0.4638 | 3 | 579 | cellular cation homeostasis |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0060349 | 5e-04 | 22.7534 | 0.1518 | 3 | 88 | bone morphogenesis |
GO:0001958 | 0.001 | 49.7754 | 0.0466 | 2 | 27 | endochondral ossification |
GO:0048562 | 0.0013 | 9.6527 | 0.4813 | 4 | 279 | embryonic organ morphogenesis |
GO:0021592 | 0.0017 | Inf | 0.0017 | 1 | 1 | fourth ventricle development |
GO:0021993 | 0.0017 | Inf | 0.0017 | 1 | 1 | initiation of neural tube closure |
GO:0060010 | 0.0017 | Inf | 0.0017 | 1 | 1 | Sertoli cell fate commitment |
GO:0031076 | 0.0018 | 35.5319 | 0.0638 | 2 | 37 | embryonic camera-type eye development |
GO:0016574 | 0.0021 | 32.7206 | 0.069 | 2 | 40 | histone ubiquitination |
GO:0045321 | 0.0024 | 4.5103 | 1.9357 | 7 | 1122 | leukocyte activation |
GO:0048701 | 0.0026 | 29.5971 | 0.0759 | 2 | 44 | embryonic cranial skeleton morphogenesis |
GO:0051572 | 0.0034 | 600.037 | 0.0035 | 1 | 2 | negative regulation of histone H3-K4 methylation |
GO:1904815 | 0.0034 | 600.037 | 0.0035 | 1 | 2 | negative regulation of protein localization to chromosome, telomeric region |
GO:0008283 | 0.0044 | 3.4439 | 3.3952 | 9 | 1968 | cell proliferation |
GO:0045669 | 0.0045 | 22.1786 | 0.1001 | 2 | 58 | positive regulation of osteoblast differentiation |
GO:0002351 | 0.0052 | 300 | 0.0052 | 1 | 3 | serotonin production involved in inflammatory response |
GO:0002554 | 0.0052 | 300 | 0.0052 | 1 | 3 | serotonin secretion by platelet |
GO:0021678 | 0.0052 | 300 | 0.0052 | 1 | 3 | third ventricle development |
GO:0033128 | 0.0052 | 300 | 0.0052 | 1 | 3 | negative regulation of histone phosphorylation |
GO:0071593 | 0.0052 | 300 | 0.0052 | 1 | 3 | lymphocyte aggregation |
GO:1901837 | 0.0052 | 300 | 0.0052 | 1 | 3 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter |
GO:1990834 | 0.0052 | 300 | 0.0052 | 1 | 3 | response to odorant |
GO:0061035 | 0.0054 | 20.0248 | 0.1104 | 2 | 64 | regulation of cartilage development |
GO:0008589 | 0.0061 | 18.8065 | 0.1173 | 2 | 68 | regulation of smoothened signaling pathway |
GO:0006366 | 0.0061 | 3.2591 | 3.5625 | 9 | 2065 | transcription from RNA polymerase II promoter |
GO:0002051 | 0.0069 | 199.9877 | 0.0069 | 1 | 4 | osteoblast fate commitment |
GO:0016554 | 0.0069 | 199.9877 | 0.0069 | 1 | 4 | cytidine to uridine editing |
GO:0021555 | 0.0069 | 199.9877 | 0.0069 | 1 | 4 | midbrain-hindbrain boundary morphogenesis |
GO:0061086 | 0.0069 | 199.9877 | 0.0069 | 1 | 4 | negative regulation of histone H3-K27 methylation |
GO:0042110 | 0.0069 | 5.9152 | 0.7729 | 4 | 448 | T cell activation |
GO:0043627 | 0.007 | 17.4767 | 0.1259 | 2 | 73 | response to estrogen |
GO:0002521 | 0.0077 | 5.7422 | 0.7953 | 4 | 461 | leukocyte differentiation |
GO:0045621 | 0.0083 | 15.9014 | 0.138 | 2 | 80 | positive regulation of lymphocyte differentiation |
GO:0034184 | 0.0086 | 149.9815 | 0.0086 | 1 | 5 | positive regulation of maintenance of mitotic sister chromatid cohesion |
GO:0060591 | 0.0086 | 149.9815 | 0.0086 | 1 | 5 | chondroblast differentiation |
GO:0048609 | 0.0091 | 4.417 | 1.3198 | 5 | 765 | multicellular organismal reproductive process |
GO:0120034 | 0.0092 | 15.122 | 0.1449 | 2 | 84 | positive regulation of plasma membrane bounded cell projection assembly |
GO:0060606 | 0.0096 | 14.7601 | 0.1484 | 2 | 86 | tube closure |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:2000502 | 0 | 1200 | 0.0054 | 2 | 3 | negative regulation of natural killer cell chemotaxis |
GO:0060326 | 1e-04 | 12.9761 | 0.4664 | 5 | 261 | cell chemotaxis |
GO:2000402 | 1e-04 | 171.3651 | 0.0161 | 2 | 9 | negative regulation of lymphocyte migration |
GO:0002689 | 4e-04 | 85.6455 | 0.0286 | 2 | 16 | negative regulation of leukocyte chemotaxis |
GO:0070098 | 4e-04 | 24.1618 | 0.1429 | 3 | 80 | chemokine-mediated signaling pathway |
GO:0045954 | 5e-04 | 70.5185 | 0.0339 | 2 | 19 | positive regulation of natural killer cell mediated cytotoxicity |
GO:0043547 | 6e-04 | 8.5584 | 0.6969 | 5 | 390 | positive regulation of GTPase activity |
GO:1901623 | 6e-04 | 63.0877 | 0.0375 | 2 | 21 | regulation of lymphocyte chemotaxis |
GO:0051336 | 7e-04 | 5.0712 | 2.037 | 8 | 1140 | regulation of hydrolase activity |
GO:0048247 | 0.0017 | 36.9074 | 0.0616 | 2 | 37 | lymphocyte chemotaxis |
GO:0002715 | 0.0018 | 36.2918 | 0.0625 | 2 | 35 | regulation of natural killer cell mediated immunity |
GO:0032078 | 0.0018 | Inf | 0.0018 | 1 | 1 | negative regulation of endodeoxyribonuclease activity |
GO:1902204 | 0.0018 | Inf | 0.0018 | 1 | 1 | positive regulation of hepatocyte growth factor receptor signaling pathway |
GO:1904155 | 0.0018 | Inf | 0.0018 | 1 | 1 | DN2 thymocyte differentiation |
GO:1904156 | 0.0018 | Inf | 0.0018 | 1 | 1 | DN3 thymocyte differentiation |
GO:0071346 | 0.0019 | 13.5295 | 0.2502 | 3 | 140 | cellular response to interferon-gamma |
GO:0045429 | 0.0024 | 30.6971 | 0.0733 | 2 | 41 | positive regulation of nitric oxide biosynthetic process |
GO:0019835 | 0.0025 | 29.9278 | 0.075 | 2 | 42 | cytolysis |
GO:0031343 | 0.0027 | 29.196 | 0.0768 | 2 | 43 | positive regulation of cell killing |
GO:0034260 | 0.0028 | 28.4991 | 0.0786 | 2 | 44 | negative regulation of GTPase activity |
GO:0042330 | 0.0029 | 5.8622 | 1.0024 | 5 | 561 | taxis |
GO:0002685 | 0.0032 | 11.353 | 0.2966 | 3 | 166 | regulation of leukocyte migration |
GO:0045087 | 0.0032 | 4.8189 | 1.4974 | 6 | 838 | innate immune response |
GO:0046373 | 0.0036 | 578.5714 | 0.0036 | 1 | 2 | L-arabinose metabolic process |
GO:0050920 | 0.0038 | 10.628 | 0.3163 | 3 | 177 | regulation of chemotaxis |
GO:0001910 | 0.004 | 23.4568 | 0.0947 | 2 | 53 | regulation of leukocyte mediated cytotoxicity |
GO:0006968 | 0.0042 | 23.0043 | 0.0965 | 2 | 54 | cellular defense response |
GO:0032729 | 0.0051 | 20.6169 | 0.1072 | 2 | 60 | positive regulation of interferon-gamma production |
GO:0002548 | 0.0055 | 19.9272 | 0.1108 | 2 | 62 | monocyte chemotaxis |
GO:0031295 | 0.0063 | 18.3886 | 0.1197 | 2 | 67 | T cell costimulation |
GO:0046209 | 0.0069 | 17.5741 | 0.1251 | 2 | 70 | nitric oxide metabolic process |
GO:0060474 | 0.0071 | 192.8333 | 0.0071 | 1 | 4 | positive regulation of flagellated sperm motility involved in capacitation |
GO:0030101 | 0.0075 | 16.8284 | 0.1304 | 2 | 73 | natural killer cell activation |
GO:0002708 | 0.0077 | 16.5936 | 0.1322 | 2 | 74 | positive regulation of lymphocyte mediated immunity |
GO:1903426 | 0.0083 | 15.9269 | 0.1376 | 2 | 77 | regulation of reactive oxygen species biosynthetic process |
GO:0072679 | 0.0089 | 144.6161 | 0.0089 | 1 | 5 | thymocyte migration |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0006955 | 0 | 28.6195 | 0.3161 | 6 | 257 | immune response |
GO:0045321 | 0 | 7.7668 | 2.2813 | 12 | 1122 | leukocyte activation |
GO:0002263 | 0 | 8.9551 | 1.342 | 9 | 660 | cell activation involved in immune response |
GO:0006954 | 0 | 8.8278 | 1.3603 | 9 | 669 | inflammatory response |
GO:0007166 | 0 | 4.8951 | 5.3434 | 16 | 2628 | cell surface receptor signaling pathway |
GO:0070098 | 0 | 29.2577 | 0.1627 | 4 | 80 | chemokine-mediated signaling pathway |
GO:0045087 | 0 | 6.9517 | 1.7039 | 9 | 838 | innate immune response |
GO:0071347 | 0 | 25.8396 | 0.183 | 4 | 90 | cellular response to interleukin-1 |
GO:0002322 | 0 | 348.2581 | 0.0102 | 2 | 5 | B cell proliferation involved in immune response |
GO:0070374 | 0 | 15.1247 | 0.3945 | 5 | 194 | positive regulation of ERK1 and ERK2 cascade |
GO:0007194 | 0 | 52.1484 | 0.0691 | 3 | 34 | negative regulation of adenylate cyclase activity |
GO:0002548 | 1e-04 | 42.1777 | 0.0841 | 3 | 44 | monocyte chemotaxis |
GO:0002687 | 1e-04 | 18.9567 | 0.246 | 4 | 121 | positive regulation of leukocyte migration |
GO:0097530 | 1e-04 | 18.7949 | 0.2481 | 4 | 122 | granulocyte migration |
GO:0031666 | 1e-04 | 174.0968 | 0.0163 | 2 | 8 | positive regulation of lipopolysaccharide-mediated signaling pathway |
GO:0030803 | 1e-04 | 35.8933 | 0.0976 | 3 | 48 | negative regulation of cyclic nucleotide biosynthetic process |
GO:0030815 | 1e-04 | 34.3617 | 0.1017 | 3 | 50 | negative regulation of cAMP metabolic process |
GO:1900372 | 1e-04 | 33.6437 | 0.1037 | 3 | 51 | negative regulation of purine nucleotide biosynthetic process |
GO:0060326 | 2e-04 | 11.1196 | 0.5307 | 5 | 261 | cell chemotaxis |
GO:0071346 | 2e-04 | 16.289 | 0.2847 | 4 | 140 | cellular response to interferon-gamma |
GO:0048247 | 2e-04 | 29.3491 | 0.1179 | 3 | 58 | lymphocyte chemotaxis |
GO:0045980 | 4e-04 | 23.0386 | 0.1484 | 3 | 73 | negative regulation of nucleotide metabolic process |
GO:0030502 | 5e-04 | 74.576 | 0.0325 | 2 | 16 | negative regulation of bone mineralization |
GO:0002275 | 6e-04 | 6.794 | 1.0553 | 6 | 519 | myeloid cell activation involved in immune response |
GO:0002444 | 6e-04 | 6.7532 | 1.0614 | 6 | 522 | myeloid leukocyte mediated immunity |
GO:0090026 | 6e-04 | 65.246 | 0.0366 | 2 | 18 | positive regulation of monocyte chemotaxis |
GO:0030593 | 7e-04 | 18.9553 | 0.1789 | 3 | 88 | neutrophil chemotaxis |
GO:0031279 | 9e-04 | 17.6989 | 0.1911 | 3 | 94 | regulation of cyclase activity |
GO:0051339 | 9e-04 | 17.5054 | 0.1932 | 3 | 95 | regulation of lyase activity |
GO:0007214 | 0.001 | 49.6959 | 0.0468 | 2 | 23 | gamma-aminobutyric acid signaling pathway |
GO:0002688 | 0.0013 | 15.6252 | 0.2155 | 3 | 106 | regulation of leukocyte chemotaxis |
GO:0032940 | 0.0013 | 4.0715 | 2.7957 | 9 | 1375 | secretion by cell |
GO:0002682 | 0.0013 | 7.1121 | 0.8434 | 5 | 479 | regulation of immune system process |
GO:0050715 | 0.0015 | 14.7596 | 0.2277 | 3 | 112 | positive regulation of cytokine secretion |
GO:0050900 | 0.0016 | 8.9959 | 0.5131 | 4 | 285 | leukocyte migration |
GO:0006049 | 0.002 | Inf | 0.002 | 1 | 1 | UDP-N-acetylglucosamine catabolic process |
GO:0006051 | 0.002 | Inf | 0.002 | 1 | 1 | N-acetylmannosamine metabolic process |
GO:0048006 | 0.002 | Inf | 0.002 | 1 | 1 | antigen processing and presentation, endogenous lipid antigen via MHC class Ib |
GO:0090122 | 0.002 | Inf | 0.002 | 1 | 1 | cholesterol ester hydrolysis involved in cholesterol transport |
GO:0009225 | 0.002 | 33.6441 | 0.0671 | 2 | 33 | nucleotide-sugar metabolic process |
GO:0030817 | 0.0022 | 12.9621 | 0.2582 | 3 | 127 | regulation of cAMP biosynthetic process |
GO:0006040 | 0.0022 | 32.5907 | 0.0691 | 2 | 34 | amino sugar metabolic process |
GO:0050921 | 0.0022 | 12.8576 | 0.2603 | 3 | 128 | positive regulation of chemotaxis |
GO:0002521 | 0.0022 | 6.1642 | 0.9373 | 5 | 461 | leukocyte differentiation |
GO:0043312 | 0.0024 | 6.0819 | 0.9495 | 5 | 467 | neutrophil degranulation |
GO:0042119 | 0.0026 | 5.9492 | 0.9699 | 5 | 477 | neutrophil activation |
GO:0045055 | 0.0027 | 4.905 | 1.4396 | 6 | 708 | regulated exocytosis |
GO:0071675 | 0.0031 | 26.7295 | 0.0834 | 2 | 41 | regulation of mononuclear cell migration |
GO:0002285 | 0.0037 | 10.6265 | 0.3131 | 3 | 154 | lymphocyte activation involved in immune response |
GO:0030808 | 0.0038 | 10.4863 | 0.3172 | 3 | 156 | regulation of nucleotide biosynthetic process |
GO:0052652 | 0.0041 | 10.2827 | 0.3233 | 3 | 159 | cyclic purine nucleotide metabolic process |
GO:0002337 | 0.0041 | 506.125 | 0.0041 | 1 | 2 | B-1a B cell differentiation |
GO:0071663 | 0.0041 | 506.125 | 0.0041 | 1 | 2 | positive regulation of granzyme B production |
GO:1904808 | 0.0041 | 506.125 | 0.0041 | 1 | 2 | positive regulation of protein oxidation |
GO:0071222 | 0.0044 | 9.9602 | 0.3335 | 3 | 164 | cellular response to lipopolysaccharide |
GO:0030799 | 0.0048 | 9.6572 | 0.3436 | 3 | 169 | regulation of cyclic nucleotide metabolic process |
GO:0019220 | 0.0051 | 3.2708 | 3.4057 | 9 | 1675 | regulation of phosphate metabolic process |
GO:0042330 | 0.0052 | 5.0234 | 1.1407 | 5 | 561 | taxis |
GO:0046651 | 0.0054 | 19.9812 | 0.1104 | 2 | 59 | lymphocyte proliferation |
GO:0005975 | 0.0056 | 4.9315 | 1.161 | 5 | 571 | carbohydrate metabolic process |
GO:0048584 | 0.0056 | 3.0497 | 4.1296 | 10 | 2031 | positive regulation of response to stimulus |
GO:0050918 | 0.006 | 18.9349 | 0.1159 | 2 | 57 | positive chemotaxis |
GO:0019262 | 0.0061 | 253.0469 | 0.0061 | 1 | 3 | N-acetylneuraminate catabolic process |
GO:2000566 | 0.0061 | 253.0469 | 0.0061 | 1 | 3 | positive regulation of CD8-positive, alpha-beta T cell proliferation |
GO:0048870 | 0.0064 | 3.3559 | 2.8832 | 8 | 1418 | cell motility |
GO:0048534 | 0.0066 | 4.0576 | 1.7222 | 6 | 847 | hematopoietic or lymphoid organ development |
GO:0070661 | 0.0067 | 17.7757 | 0.1236 | 2 | 66 | leukocyte proliferation |
GO:0071216 | 0.0068 | 8.5154 | 0.3884 | 3 | 191 | cellular response to biotic stimulus |
GO:0043900 | 0.0068 | 5.8838 | 0.7625 | 4 | 375 | regulation of multi-organism process |
GO:0045670 | 0.0068 | 17.6468 | 0.124 | 2 | 61 | regulation of osteoclast differentiation |
GO:0050670 | 0.0075 | 8.2062 | 0.4026 | 3 | 198 | regulation of lymphocyte proliferation |
GO:2000391 | 0.0081 | 168.6875 | 0.0081 | 1 | 4 | positive regulation of neutrophil extravasation |
GO:0050776 | 0.0086 | 3.822 | 1.8218 | 6 | 896 | regulation of immune response |
GO:0070663 | 0.0086 | 7.7626 | 0.425 | 3 | 209 | regulation of leukocyte proliferation |
GO:0036230 | 0.0089 | 145.5648 | 0.0089 | 1 | 5 | granulocyte activation |
GO:0070167 | 0.0091 | 15.0799 | 0.1444 | 2 | 71 | regulation of biomineral tissue development |
GO:0042113 | 0.0096 | 7.4687 | 0.4412 | 3 | 217 | B cell activation |
GOMFID | Pvalue | OddsRatio | ExpCount | Count | Size | Term |
GO:0006955 | 0 | 24.5276 | 0.3512 | 6 | 257 | immune response |
GO:0070374 | 0 | 17.6159 | 0.4184 | 6 | 194 | positive regulation of ERK1 and ERK2 cascade |
GO:0007166 | 0 | 4.9136 | 5.6673 | 17 | 2628 | cell surface receptor signaling pathway |
GO:0006954 | 0 | 8.1477 | 1.4427 | 9 | 669 | inflammatory response |
GO:0045321 | 0 | 6.2228 | 2.4196 | 11 | 1122 | leukocyte activation |
GO:0070098 | 0 | 27.3667 | 0.1725 | 4 | 80 | chemokine-mediated signaling pathway |
GO:0071347 | 0 | 24.1695 | 0.1941 | 4 | 90 | cellular response to interleukin-1 |
GO:0002322 | 0 | 327.1111 | 0.0108 | 2 | 5 | B cell proliferation involved in immune response |
GO:0007194 | 1e-04 | 48.8831 | 0.0733 | 3 | 34 | negative regulation of adenylate cyclase activity |
GO:0002263 | 1e-04 | 7.0634 | 1.4233 | 8 | 660 | cell activation involved in immune response |
GO:0002548 | 1e-04 | 39.361 | 0.0896 | 3 | 44 | monocyte chemotaxis |
GO:0031666 | 1e-04 | 163.5253 | 0.0173 | 2 | 8 | positive regulation of lipopolysaccharide-mediated signaling pathway |
GO:0002687 | 1e-04 | 17.7315 | 0.2609 | 4 | 121 | positive regulation of leukocyte migration |
GO:0097530 | 1e-04 | 17.5801 | 0.2631 | 4 | 122 | granulocyte migration |
GO:0030803 | 1e-04 | 33.6458 | 0.1035 | 3 | 48 | negative regulation of cyclic nucleotide biosynthetic process |
GO:0030815 | 2e-04 | 32.2101 | 0.1078 | 3 | 50 | negative regulation of cAMP metabolic process |
GO:1900372 | 2e-04 | 31.5371 | 0.11 | 3 | 51 | negative regulation of purine nucleotide biosynthetic process |
GO:0071346 | 2e-04 | 15.2362 | 0.3019 | 4 | 140 | cellular response to interferon-gamma |
GO:0060326 | 2e-04 | 10.377 | 0.5628 | 5 | 261 | cell chemotaxis |
GO:0048247 | 3e-04 | 27.5114 | 0.1251 | 3 | 58 | lymphocyte chemotaxis |
GO:0045087 | 3e-04 | 5.4851 | 1.8071 | 8 | 838 | innate immune response |
GO:0045980 | 5e-04 | 21.596 | 0.1574 | 3 | 73 | negative regulation of nucleotide metabolic process |
GO:0030502 | 5e-04 | 70.0476 | 0.0345 | 2 | 16 | negative regulation of bone mineralization |
GO:0090026 | 7e-04 | 61.2841 | 0.0388 | 2 | 18 | positive regulation of monocyte chemotaxis |
GO:0048584 | 7e-04 | 3.6633 | 4.3799 | 12 | 2031 | positive regulation of response to stimulus |
GO:0002275 | 8e-04 | 6.3247 | 1.1192 | 6 | 519 | myeloid cell activation involved in immune response |
GO:0002444 | 8e-04 | 6.2867 | 1.1257 | 6 | 522 | myeloid leukocyte mediated immunity |
GO:0030593 | 9e-04 | 17.7684 | 0.1898 | 3 | 88 | neutrophil chemotaxis |
GO:0031279 | 0.0011 | 16.5907 | 0.2027 | 3 | 94 | regulation of cyclase activity |
GO:0051339 | 0.0011 | 16.4093 | 0.2049 | 3 | 95 | regulation of lyase activity |
GO:0007214 | 0.0011 | 46.6782 | 0.0496 | 2 | 23 | gamma-aminobutyric acid signaling pathway |
GO:0043900 | 0.0012 | 7.1284 | 0.8087 | 5 | 375 | regulation of multi-organism process |
GO:0002688 | 0.0015 | 14.6468 | 0.2286 | 3 | 106 | regulation of leukocyte chemotaxis |
GO:0006049 | 0.0022 | Inf | 0.0022 | 1 | 1 | UDP-N-acetylglucosamine catabolic process |
GO:0006051 | 0.0022 | Inf | 0.0022 | 1 | 1 | N-acetylmannosamine metabolic process |
GO:0048006 | 0.0022 | Inf | 0.0022 | 1 | 1 | antigen processing and presentation, endogenous lipid antigen via MHC class Ib |
GO:0090122 | 0.0022 | Inf | 0.0022 | 1 | 1 | cholesterol ester hydrolysis involved in cholesterol transport |
GO:0046651 | 0.0022 | 8.1306 | 0.5542 | 4 | 257 | lymphocyte proliferation |
GO:0009225 | 0.0023 | 31.6012 | 0.0712 | 2 | 33 | nucleotide-sugar metabolic process |
GO:0006040 | 0.0024 | 30.6117 | 0.0733 | 2 | 34 | amino sugar metabolic process |
GO:0030817 | 0.0026 | 12.1505 | 0.2739 | 3 | 127 | regulation of cAMP biosynthetic process |
GO:0050921 | 0.0026 | 12.0525 | 0.276 | 3 | 128 | positive regulation of chemotaxis |
GO:0050776 | 0.0026 | 4.3043 | 1.9322 | 7 | 896 | regulation of immune response |
GO:0007186 | 0.0027 | 3.9189 | 2.5024 | 8 | 1229 | G-protein coupled receptor signaling pathway |
GO:0070661 | 0.0028 | 7.582 | 0.593 | 4 | 275 | leukocyte proliferation |
GO:0002521 | 0.0029 | 5.7526 | 0.9941 | 5 | 461 | leukocyte differentiation |
GO:0043312 | 0.0031 | 5.6757 | 1.0071 | 5 | 467 | neutrophil degranulation |
GO:0043408 | 0.0032 | 4.7278 | 1.4772 | 6 | 685 | regulation of MAPK cascade |
GO:0042119 | 0.0034 | 5.5519 | 1.0287 | 5 | 477 | neutrophil activation |
GO:0071675 | 0.0035 | 25.1064 | 0.0884 | 2 | 41 | regulation of mononuclear cell migration |
GO:0045055 | 0.0037 | 4.5662 | 1.5268 | 6 | 708 | regulated exocytosis |
GO:0002337 | 0.0043 | 476.2941 | 0.0043 | 1 | 2 | B-1a B cell differentiation |
GO:1904808 | 0.0043 | 476.2941 | 0.0043 | 1 | 2 | positive regulation of protein oxidation |
GO:0030808 | 0.0046 | 9.8297 | 0.3364 | 3 | 156 | regulation of nucleotide biosynthetic process |
GO:0052652 | 0.0048 | 9.6388 | 0.3429 | 3 | 159 | cyclic purine nucleotide metabolic process |
GO:0071222 | 0.0052 | 9.3366 | 0.3537 | 3 | 164 | cellular response to lipopolysaccharide |
GO:0010647 | 0.0054 | 3.2042 | 3.4245 | 9 | 1588 | positive regulation of cell communication |
GO:0023056 | 0.0055 | 3.1907 | 3.4375 | 9 | 1594 | positive regulation of signaling |
GO:0030799 | 0.0057 | 9.0525 | 0.3644 | 3 | 169 | regulation of cyclic nucleotide metabolic process |
GO:0019262 | 0.0065 | 238.1324 | 0.0065 | 1 | 3 | N-acetylneuraminate catabolic process |
GO:0042330 | 0.0067 | 4.6879 | 1.2098 | 5 | 561 | taxis |
GO:0050918 | 0.0067 | 17.7851 | 0.1229 | 2 | 57 | positive chemotaxis |
GO:0045670 | 0.0076 | 16.5752 | 0.1315 | 2 | 61 | regulation of osteoclast differentiation |
GO:0019220 | 0.0077 | 3.0188 | 3.6121 | 9 | 1675 | regulation of phosphate metabolic process |
GO:0032940 | 0.0077 | 3.214 | 2.9652 | 8 | 1375 | secretion by cell |
GO:0071216 | 0.008 | 7.9822 | 0.4119 | 3 | 191 | cellular response to biotic stimulus |
GO:0002925 | 0.0086 | 158.7451 | 0.0086 | 1 | 4 | positive regulation of humoral immune response mediated by circulating immunoglobulin |
GO:2000391 | 0.0086 | 158.7451 | 0.0086 | 1 | 4 | positive regulation of neutrophil extravasation |
GO:0048534 | 0.0088 | 3.7773 | 1.8266 | 6 | 847 | hematopoietic or lymphoid organ development |
GO:0036230 | 0.0095 | 135.5086 | 0.0095 | 1 | 5 | granulocyte activation |